Plants of the genus Terminalia are amongst the most widely used plants for traditional
medicinal purposes worldwide. Many species are used for their antibacterial, antifungal …

Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver
necrosis and liver failure. APAP-induced liver injury is associated with glutathione depletion …

Objective To evaluate the ameliorator property of silymarin or/and Nigella sativa (N. sativa)
extract against N-acetyl-p-aminophenol (APAP)-induced injury in male mice at the …

There is increasing amount of evidence for sex variation in drug efficiency and toxicity
profiles. Women are more susceptible than men to acute liver injury from xenobiotics. In …

Context: Paracetamol overdose is a predominant cause of hepatotoxicity in both humans
and experimental animals. Objective: In this study, we investigated the protective effect of …

Tuberculosis is still a major problem in some developed and developing countries. The poor
compliance to the treatment of tuberculosis patients due to the adverse events was …

Oxidative insult by free radicals has been implicated in drug-induced hepatic damage and
this has resulted in frequent episodes of liver disorders. Therapeutic efficacy of antioxidants …

The zebrafish embryo (ZFE) is a promising alternative, non-rodent model in toxicology,
which has an advantage over the traditionally used models as it contains complete …

Cumin is an annual herb from Apiaceae family. Cumin seeds possess good content of
phenolic compounds which show considerable free radical scavenging activity …

Ethnopharmacological relevance Vitex doniana fruits are locally used in Nigeria as a
remedy in the treatment of jaundice and liver related disease. The effect of methanolic …