Solute carrier (SLC) transporters—a family of more than 300 membrane-bound proteins that
facilitate the transport of a wide array of substrates across biological membranes—have …

Abstract The Framingham Heart Study (FHS) has conducted seminal research defining
cardiovascular disease (CVD) risk factors and fundamentally shaping public health …

Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is
largely based on genome-wide association study (GWAS) analysis of common SNPs …

Genome-wide association studies (GWASs) have identified many genetic variants
underlying complex traits. Many detected genetic loci harbor variants that associate with …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Until recently, significant advances in our understanding of the mechanisms of blood
pressure regulation arose from studies of monogenic forms of hypertension and …

Understanding the pathogenesis of neurodevelopmental disorders has proven to be
challenging. Using autism spectrum disorder (ASD) as a paradigmatic neurodevelopmental …

We carried out a trans-ancestry genome-wide association and replication study of blood
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …

Background The nature and underlying mechanisms of an inverse association between
adult height and the risk of coronary artery disease (CAD) are unclear. Methods We used a …

Background Potentially modifiable risk factors including obesity, diabetes, hypertension, and
smoking are associated with Alzheimer disease (AD) and represent promising targets for …