Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies
Life-threatening invasive fungal infections are becoming increasingly common, at least in
part due to the prevalence of medical interventions resulting in immunosuppression …
part due to the prevalence of medical interventions resulting in immunosuppression …
Fungal morphogenesis
Morphogenesis in fungi is often induced by extracellular factors and executed by fungal
genetic factors. Cell surface changes and alterations of the microenvironment often …
genetic factors. Cell surface changes and alterations of the microenvironment often …
Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection
DL Wiesner, CA Specht, CK Lee, KD Smith… - PLoS …, 2015 - journals.plos.org
Pulmonary mycoses are often associated with type-2 helper T (Th2) cell responses.
However, mechanisms of Th2 cell accumulation are multifactorial and incompletely known …
However, mechanisms of Th2 cell accumulation are multifactorial and incompletely known …
Systematic functional profiling of transcription factor networks in Cryptococcus neoformans
KW Jung, DH Yang, S Maeng, KT Lee, YS So… - Nature …, 2015 - nature.com
Cryptococcus neoformans causes life-threatening meningoencephalitis in humans, but its
overall biological and pathogenic regulatory circuits remain elusive, particularly due to the …
overall biological and pathogenic regulatory circuits remain elusive, particularly due to the …
Polyploid titan cells produce haploid and aneuploid progeny to promote stress adaptation
Cryptococcus neoformans is a major life-threatening fungal pathogen. In response to the
stress of the host environment, C. neoformans produces large polyploid titan cells. Titan cell …
stress of the host environment, C. neoformans produces large polyploid titan cells. Titan cell …
The Cryptococcus neoformans Alkaline Response Pathway: Identification of a Novel Rim Pathway Activator
The Rim101/PacC transcription factor acts in a fungal-specific signaling pathway
responsible for sensing extracellular pH signals. First characterized in ascomycete fungi …
responsible for sensing extracellular pH signals. First characterized in ascomycete fungi …
The cAMP/protein kinase A signaling pathway in pathogenic basidiomycete fungi: Connections with iron homeostasis
A number of pathogenic species of basidiomycete fungi are either life-threatening
pathogens of humans or major economic pests for crop production. Sensing the host is a key …
pathogens of humans or major economic pests for crop production. Sensing the host is a key …
Shift and adapt: the costs and benefits of karyotype variations
AC Gerstein, J Berman - Current opinion in Microbiology, 2015 - Elsevier
Highlights•We review recent studies of ploidy and aneuploidy variants and how they affect
fitness.•Parasexual ploidy shifts appear in fungal microbial species in the absence of …
fitness.•Parasexual ploidy shifts appear in fungal microbial species in the absence of …
Investigating phagosome dynamics of microbial pathogens
LM Smith - 2015 - etheses.bham.ac.uk
Many microbial pathogens are able to evade killing by phagocytes of the innate immune
system. This thesis focuses on two pathogens: the fungal pathogen\(Cryptococcus\) …
system. This thesis focuses on two pathogens: the fungal pathogen\(Cryptococcus\) …
The Regulation and Consequences of Type-2 Helper T Cells During Pulmonary Cryptococcal Infection
D Wiesner - 2015 - conservancy.umn.edu
Pathogens are microbes that infect hosts and cause disease. There are many forms of
pathogens, including: bacteria, viruses, parasites, and fungi. In particular, fungi are found …
pathogens, including: bacteria, viruses, parasites, and fungi. In particular, fungi are found …