Molecular regulation of toll-like receptors in asthma and COPD
Asthma and chronic obstructive pulmonary disease (COPD) have both been historically
associated with significant morbidity and financial burden. These diseases can be induced …
associated with significant morbidity and financial burden. These diseases can be induced …
Role of macrophage migration inhibitory factor in age-related lung disease
The prevalence of many common respiratory disorders, including pneumonia, chronic
obstructive lung disease, pulmonary fibrosis, and lung cancer, increases with age. Little is …
obstructive lung disease, pulmonary fibrosis, and lung cancer, increases with age. Little is …
Macrophage‐specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP‐9 pathways
C Trocme, C Deffert, J Cachat, Y Donati… - The Journal of …, 2015 - Wiley Online Library
Reactive oxygen species (ROS) participate in the pathogenesis of emphysema. Among ROS‐
producing enzymes, NOX NADPH oxidases are thought to be responsible for tissue injury …
producing enzymes, NOX NADPH oxidases are thought to be responsible for tissue injury …
[HTML][HTML] Inhibition of the phospholipase A2 activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia
B Benipal, SI Feinstein, S Chatterjee, C Dodia… - Redox biology, 2015 - Elsevier
Lung injury associated with hyperoxia reflects in part the secondary effects of pulmonary
inflammation and the associated production of reactive oxygen species due to activation of …
inflammation and the associated production of reactive oxygen species due to activation of …
Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five …
M Cabanski, B Fields, S Boue, N Boukharov… - Inflammation …, 2015 - Springer
Background Mouse models are useful for studying cigarette smoke (CS)-induced chronic
pulmonary pathologies such as lung emphysema. To enhance translation of large-scale …
pulmonary pathologies such as lung emphysema. To enhance translation of large-scale …
NOX modifiers—just a step away from application in the therapy of airway inflammation?
J Wieczfinska, M Sokolowska… - Antioxidants & redox …, 2015 - liebertpub.com
Significance: NADPH oxidase (NOX) enzymes, which are widely expressed in different
airway cell types, not only contribute to the maintenance of physiological processes in the …
airway cell types, not only contribute to the maintenance of physiological processes in the …
MD2 expression is reduced in large airways of smokers and COPD smokers
E Pace, M Ferraro, G Chiappara, P Vitulo… - Molecular and cellular …, 2015 - Springer
Abstract Toll-like receptor 4 (TLR4) signaling requires a number of accessory proteins to
initiate a signal. MD-2 is one of the accessory proteins with a relevant role in …
initiate a signal. MD-2 is one of the accessory proteins with a relevant role in …
COPD: an early disease
V Margelidon-Cozzolino, K Chbini… - Revue de …, 2015 - europepmc.org
Résumé Cette revue générale aborde les mécanismes qui sous-tendent les phénomènes
génétiques dans la BPCO. L'inflammation de la paroi bronchique met en jeu de nombreux …
génétiques dans la BPCO. L'inflammation de la paroi bronchique met en jeu de nombreux …
Shortened Title: MIF in Lung Aging 1 2 3 4 5
92 The lungs are vulnerable to age and age-related diseases. Aging reduces ventilatory
capacity 93 and increases vulnerability to environmental stressors, including inhaled …
capacity 93 and increases vulnerability to environmental stressors, including inhaled …