Potent actions of ATP in the central nervous system (CNS) were reported in the late 1940's,
but cloning and characterisation of receptors for purines and pyrimidines did not take place …

In this work, we have highlighted data reported in the literature trying to draw a complete
picture of the structures and biological activity of agonists and orthosteric antagonists of P2X …

This review considers the expression and roles of P2X receptors in the cardiovascular
system in health and disease and their potential as therapeutic targets. P2X receptors are …

Inflammatory damage in many neurodegenerative diseases is restricted to certain regions of
the CNS, and while microglia have long been implicated in the pathology of many of these …

P2X receptors constitute a seven-member family (P2X1-7) of extracellular ATP-gated cation
channels of widespread expression. Because P2X receptors have been implicated in …

Abstract Adenosine-5′-triphosphate is released by neuroendocrine, endocrine, and other
cell types and acts as an extracellular agonist for ligand-gated P2X cationic channels and G …

Purinergic signaling in the nervous system has been the focus of a considerable number of
studies since the 1970s. The P2X and P2Y receptors are involved in the initiation of …

Dopaminergic signaling pathways are conserved between mammals and Drosophila, but
the factors important for maintaining the functional pool of synaptic dopamine are not fully …

Purine nucleotides, such as ATP and ADP, activate ionotropic P2X and metabotropic P2Y
receptors to regulate neurotransmitter release in the peripheral as well as central nervous …

P2X receptors are ligand-gated ion channels sensitive to extracellular nucleotides formed by
the assembling of three equal or different P2X subunits. In this work we report, for the first …