The extracellular matrix (ECM) is a major component of the biomechanical environment with
which cells interact, and it plays important roles in both normal development and disease …

Cells respond to biochemical and biomechanical stimuli through changes in their
proliferation, apoptosis, differentiation, secretion, contraction, motility, and adhesion. To …

Mechanical strain regulates the development, organization, and function of multicellular
tissues, but mechanisms linking mechanical strain and cell-cell junction proteins to cellular …

A cell receives mechanical cues from its surrounding microenvironment and transduces this
mechanical information into a biochemical signal within the cell, ultimately resulting in …

In tissue engineering research, aligned electrospun ultrafine fibers have been shown to
regulate cellular alignment and relevant functional expression, but the imposed effect of …

The development of atherosclerosis involves phenotypic changes among vascular smooth
muscle cells (VSMCs) that correlate with stiffening and remodeling of the extracellular matrix …

The design of 3D constructs with adequate properties to instruct and guide cells both in vitro
and in vivo is one of the major focuses of tissue engineering. Successful tissue regeneration …

The deterioration of retinal tissue in advanced stages of retinitis pigmentosa and age-related
macular degeneration and the lack of signaling cues for laminar regeneration are significant …

A growing number of studies are revealing that cells reorganize their cytoskeleton when
exposed to conditions of microgravity. Most, if not all, of the structural changes observed on …

Cells respond to mechanical cues from the substrate to which they are attached. These
mechanical cues drive cell migration, proliferation, differentiation, and survival. Previous …