Loss of protein homeostasis (proteostasis) is a common feature of aging and disease that is
characterized by the appearance of nonnative protein aggregates in various tissues. Protein …

Mammalian cells remove misfolded proteins using various proteolytic systems, including the
ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and …

Through a comprehensive analysis of organellar markers in mouse models of Alzheimer's
disease, we document a massive accumulation of lysosome-like organelles at amyloid …

TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …

Amyloid-β proteins (Aβ) of 42 (Aβ42) and 40 aa (Aβ40) accumulate as senile plaques (SP)
and cerebrovascular amyloid protein deposits that are defining diagnostic features of …

Most neurodegenerative diseases that afflict humans are associated with the
intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a …

Chaperone-mediated autophagy (CMA) selectively degrades a subset of cytosolic proteins
in lysosomes. A potent physiological activator of CMA is nutrient deprivation, a condition in …

Accumulation of dysfunctional mitochondria is one of the hallmarks in Alzheimer's disease
(AD). Mitophagy, a selective autophagy for eliminating damaged mitochondria, constitutes a …

Autophagy is a vesicle and lysosome-mediated degradative pathway that is essential for
protein homeostasis and cell health. In particular, compared to nonneuronal cells, neurons …

Neurons are highly specialized postmitotic cells that depend on dynamic cellular processes
for their proper function. These include among others, neuronal growth and maturation …