Recent neuroimaging studies suggest that the brain adapts with pain, as well as imparts risk
for developing chronic pain. Within this context, we revisit the concepts for nociception, acute …

Somatosensory neurons mediate our sense of touch. They are critically involved in
transducing pain and itch sensations under physiological and pathological conditions, along …

Chronic itch is a prevalent and debilitating condition for which few effective therapies are
available. We harnessed the natural variation across genetically distinct mouse strains to …

Intense noise damages the cochlear organ of Corti, particularly the outer hair cells
(OHCs)[1]; however, this epithelium is not innervated by nociceptors of somatosensory …

Devices, systems and methods are provided for targeted treatment of a variety of conditions,
particularly conditions that are associated with or influenced by the nervous system, such as …

The skin is a highly sensitive organ. It is densely innervated with different types of sensory
nerve endings, which discriminate between pain, temperature and touch. Autonomic nerve …

Some embodiments of the present invention provide stimulation systems and components
for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through …

A system includes a lead having a lead body and at least one electrode; and a retention
feature disposed along the lead body proximal to the at least one electrode and configured …

In the peripheral sensory nervous system the neuronal expression of voltage-gated sodium
channels (Na vs) is very important for the transmission of nociceptive information since they …

Pyruvate dehydrogenase kinases (PDK1–4) are mitochondrial metabolic regulators that
serve as decision makers via modulation of pyruvate dehydrogenase (PDH) activity to …