The epidemiology of hepatocellular carcinoma (HCC) is characterized by dynamic temporal
trends, several major established (ie, HCV, HBV, alcohol) and emerging (ie, diabetes …

The epidemiology of hepatitis B virus (HBV) infection is geographically diverse, with
population prevalence, age and mode of acquisition, and likelihood of progression to …

Vaccines and autoimmunity are linked fields. Vaccine efficacy is based on whether host
immune response against an antigen can elicit a memory T-cell response over time …

The last 50 years of hepatitis B research has resulted in the development of effective
screening assays for surveillance, vaccines for prevention and antiviral drugs that …

HBV infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Although
HBV infection can be efficiently prevented by vaccination, and treatments are available, to …

Changes in fertility and life expectancy are leading to major changes in the structure of the
global population and, in turn, in the scale of the cancer problem worldwide and at every …

The recent approval of two immune checkpoint inhibitors for the treatment of malignant
melanoma has sparked great interest by physicians and basic scientists searching for novel …

Hepatocellular carcinoma is a major problem in Asia because of the presence of multiple
risk factors in the region such as endemicity of hepatitis B and significant contamination of …

Hepatocellular carcinoma (HCC) is the sixth most prevalent malignancy worldwide and is a
rising cause of cancer related mortality. Risk factors for HCC are well documented and …

Background The number of hepatocellular carcinoma (HCC) patients with non-viral
etiologies is increasing in Japan. We conducted a nation-wide survey to examine the …