Principles in the design of ligand-targeted cancer therapeutics and imaging agents

M Srinivasarao, CV Galliford, PS Low - Nature reviews Drug discovery, 2015 - nature.com
Most cancer drugs are designed to interfere with one or more events in cell proliferation or
survival. As healthy cells may also need to proliferate and avoid apoptosis, anticancer …

[HTML][HTML] PSMA ligands for radionuclide imaging and therapy of prostate cancer: clinical status

S Lütje, S Heskamp, AS Cornelissen, TD Poeppel… - Theranostics, 2015 - ncbi.nlm.nih.gov
Prostate cancer (PCa) is the most common malignancy in men worldwide, leading to
substantial morbidity and mortality. At present, imaging of PCa has become increasingly …

Preclinical evaluation of a tailor-made DOTA-conjugated PSMA inhibitor with optimized linker moiety for imaging and endoradiotherapy of prostate cancer

M Benešová, M Schäfer, U Bauder-Wüst… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Despite many advances in the past years, the treatment of metastatic prostate cancer still
remains challenging. In recent years, prostate-specific membrane antigen (PSMA) inhibitors …

68Ga-and 177Lu-labeled PSMA I&T: optimization of a PSMA-targeted theranostic concept and first proof-of-concept human studies

M Weineisen, M Schottelius, J Simecek… - Journal of Nuclear …, 2015 - Soc Nuclear Med
On the basis of the high and consistent expression of prostate-specific membrane antigen
(PSMA) in metastatic prostate cancer (PC), the goal of this study was the development …

[HTML][HTML] Initial Evaluation of [18F]DCFPyL for Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer

Z Szabo, E Mena, SP Rowe, D Plyku, R Nidal… - Molecular imaging and …, 2015 - Springer
Purpose Prostate-specific membrane antigen (PSMA) is a recognized target for imaging
prostate cancer. Here we present initial safety, biodistribution, and radiation dosimetry …

[HTML][HTML] Prostate-specific membrane antigen as a target for cancer imaging and therapy

AP Kiess, SR Banerjee, RC Mease… - The quarterly journal …, 2015 - ncbi.nlm.nih.gov
The prostate-specific membrane antigen (PSMA) is a molecular target whose use has
resulted in some of the most productive work toward imaging and treating prostate cancer …

[HTML][HTML] [111In]PSMA-I&T: expanding the spectrum of PSMA-I&T applications towards SPECT and radioguided surgery

M Schottelius, M Wirtz, M Eiber, T Maurer, HJ Wester - EJNMMI research, 2015 - Springer
Background The relevance of prostate-specific membrane antigen (PSMA) targeting in the
clinical management of prostate cancer (PCa) is continually increasing, entailing the …

Synthesis and Evaluation of GdIII‐Based Magnetic Resonance Contrast Agents for Molecular Imaging of Prostate‐Specific Membrane Antigen

SR Banerjee, EJ Ngen, MW Rotz… - Angewandte Chemie …, 2015 - Wiley Online Library
Magnetic resonance (MR) imaging is advantageous because it concurrently provides
anatomic, functional, and molecular information. MR molecular imaging can combine the …

[HTML][HTML] Development of a Single Vial Kit Solution for Radiolabeling of 68Ga-DKFZ-PSMA-11 and Its Performance in Prostate Cancer Patients

T Ebenhan, M Vorster, B Marjanovic-Painter… - Molecules, 2015 - mdpi.com
Prostate-specific membrane antigen (PSMA), a type II glycoprotein, is highly expressed in
almost all prostate cancers. By playing such a universal role in the disease, PSMA provides …

Tenascin-C: Exploitation and collateral damage in cancer management

C Spenlé, F Saupe, K Midwood, H Burckel… - Cell adhesion & …, 2015 - Taylor & Francis
Despite an increasing knowledge about the causes of cancer, this disease is difficult to cure
and still causes far too high a death rate. Based on advances in our understanding of …