Principles in the design of ligand-targeted cancer therapeutics and imaging agents
M Srinivasarao, CV Galliford, PS Low - Nature reviews Drug discovery, 2015 - nature.com
Most cancer drugs are designed to interfere with one or more events in cell proliferation or
survival. As healthy cells may also need to proliferate and avoid apoptosis, anticancer …
survival. As healthy cells may also need to proliferate and avoid apoptosis, anticancer …
[HTML][HTML] PSMA ligands for radionuclide imaging and therapy of prostate cancer: clinical status
S Lütje, S Heskamp, AS Cornelissen, TD Poeppel… - Theranostics, 2015 - ncbi.nlm.nih.gov
Prostate cancer (PCa) is the most common malignancy in men worldwide, leading to
substantial morbidity and mortality. At present, imaging of PCa has become increasingly …
substantial morbidity and mortality. At present, imaging of PCa has become increasingly …
Preclinical evaluation of a tailor-made DOTA-conjugated PSMA inhibitor with optimized linker moiety for imaging and endoradiotherapy of prostate cancer
M Benešová, M Schäfer, U Bauder-Wüst… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Despite many advances in the past years, the treatment of metastatic prostate cancer still
remains challenging. In recent years, prostate-specific membrane antigen (PSMA) inhibitors …
remains challenging. In recent years, prostate-specific membrane antigen (PSMA) inhibitors …
68Ga-and 177Lu-labeled PSMA I&T: optimization of a PSMA-targeted theranostic concept and first proof-of-concept human studies
M Weineisen, M Schottelius, J Simecek… - Journal of Nuclear …, 2015 - Soc Nuclear Med
On the basis of the high and consistent expression of prostate-specific membrane antigen
(PSMA) in metastatic prostate cancer (PC), the goal of this study was the development …
(PSMA) in metastatic prostate cancer (PC), the goal of this study was the development …
[HTML][HTML] Initial Evaluation of [18F]DCFPyL for Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer
Purpose Prostate-specific membrane antigen (PSMA) is a recognized target for imaging
prostate cancer. Here we present initial safety, biodistribution, and radiation dosimetry …
prostate cancer. Here we present initial safety, biodistribution, and radiation dosimetry …
[HTML][HTML] Prostate-specific membrane antigen as a target for cancer imaging and therapy
The prostate-specific membrane antigen (PSMA) is a molecular target whose use has
resulted in some of the most productive work toward imaging and treating prostate cancer …
resulted in some of the most productive work toward imaging and treating prostate cancer …
[HTML][HTML] [111In]PSMA-I&T: expanding the spectrum of PSMA-I&T applications towards SPECT and radioguided surgery
M Schottelius, M Wirtz, M Eiber, T Maurer, HJ Wester - EJNMMI research, 2015 - Springer
Background The relevance of prostate-specific membrane antigen (PSMA) targeting in the
clinical management of prostate cancer (PCa) is continually increasing, entailing the …
clinical management of prostate cancer (PCa) is continually increasing, entailing the …
Synthesis and Evaluation of GdIII‐Based Magnetic Resonance Contrast Agents for Molecular Imaging of Prostate‐Specific Membrane Antigen
Magnetic resonance (MR) imaging is advantageous because it concurrently provides
anatomic, functional, and molecular information. MR molecular imaging can combine the …
anatomic, functional, and molecular information. MR molecular imaging can combine the …
[HTML][HTML] Development of a Single Vial Kit Solution for Radiolabeling of 68Ga-DKFZ-PSMA-11 and Its Performance in Prostate Cancer Patients
Prostate-specific membrane antigen (PSMA), a type II glycoprotein, is highly expressed in
almost all prostate cancers. By playing such a universal role in the disease, PSMA provides …
almost all prostate cancers. By playing such a universal role in the disease, PSMA provides …
Tenascin-C: Exploitation and collateral damage in cancer management
C Spenlé, F Saupe, K Midwood, H Burckel… - Cell adhesion & …, 2015 - Taylor & Francis
Despite an increasing knowledge about the causes of cancer, this disease is difficult to cure
and still causes far too high a death rate. Based on advances in our understanding of …
and still causes far too high a death rate. Based on advances in our understanding of …