The incidence of diabetes mellitus (DM) continues to rise and has quickly become one of the
most prevalent and costly chronic diseases worldwide. A close link exists between DM and …

In this review, the importance of growth hormone (GH) for the maintenance of normal cardiac
function in adult life is discussed. Physiological effects of GH and underlying mechanisms for …

Metabolic syndrome is a cluster of risk factors including obesity, dyslipidemia, hypertension,
and insulin resistance. A number of theories have been speculated for the pathogenesis of …

Background Insulin-like growth factor-1 (IGF-1) promotes the survival of cardiomyocytes by
activating type 1 IGF receptor (IGF-1R). Within the myocardium, IGF-1 action is modulated by …

Through a high-fat diet, obesity leads to cardiomyocyte dysfunction and apoptosis. In
addition, there is no evidence that probiotics have potential health effects associated with …

Objective: The physiopathological mechanisms implicated in hypertensive heart disease are
multi-factorial, including myocyte hypertrophy, apoptosis and myocardial remodelling. In this …

** Correspondence should be addressed to: Tohru Minamino, MD, Ph. D., Department of
Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and …

The insulin-like growth factor-I (IGF-I) is an important growth factor which regulates a variety
of cellular responses and has important roles in multiple biological systems. IGF-I is …

Arsenic trioxide (ATO) is among the first-line chemotherapeutic drugs used in oncological
practice. It has shown substantial efficacy in treating patients with relapsed or refractory …

Aberrant vascular remodelling underlies the pathogenesis of major cardiovascular diseases
(CVD), such as atherosclerosis and hypertension. Abnormal growth, migration and …