Opioid analgesics have become a cornerstone in the treatment of moderate to severe pain,
resulting in a steady rise of opioid prescriptions. Subsequently, there has been a striking …

Purpose Chronic pain is often challenging to address appropriately. Although patients with
severe chronic pain may respond to treatment with an opioid analgesic, opioids are often …

Background Interindividual variability in methadone disposition remains unexplained, and
methadone accidental overdose in pain therapy is a significant public health problem …

The primary purpose of this study was to examine the association between self-reports of
medication side effects and pain-related activity interference in patients with chronic pain …

Study objective To inform the development of interventions that could improve patient
engagement around the risks and benefits of alternative approaches to pain management in …

Purpose Tapentadol extended release (ER) has demonstrated efficacy and safety for the
management of moderate to severe, chronic pain in adults. This study evaluated the long …

Abstract Background and Objectives Suboxone® is a sublingual tablet of buprenorphine/
naloxone, approved for the treatment of opioid dependence. The objective of this study was …

Introduction: Strategies have been implemented to decrease the large proportion of
individuals misusing abusable prescription medications. Abuse-deterrent formulations …

Background and Objectives This study was designed to test whether a brief quantitative
sensory testing assessment could be used to detect hyperalgesia in patients with suspected …

Opioids are the cornerstone of pain treatment in burn patients. Undertreatment of pain has
been associated with psychological sequela. However, prescription opioids have been …