Cell cultures are important material of study for the variety of advantages that they offer. Both
established continuous cell lines and primary cell cultures continue to be invaluable for …

Cancer invasion and the ability of malignant tumor cells for directed migration and
metastasis have remained a focus of research for many years. Numerous studies have …

The behavior of cancer cells is strongly influenced by the properties of extracellular
microenvironments, including topology, mechanics and composition. As topological and …

When cells come in contact with an adhesive matrix, they begin to spread and migrate with a
speed that depends on the stiffness of the extracellular matrix. On a flat surface, migration …

The role of soluble messengers in directing cellular behaviours has been recognized for
decades. However, many cellular processes, including adhesion, migration and stem cell …

Hydrogels are used for 3D in vitro assays and tissue engineering and regeneration
purposes. For a thorough interpretation of this technology, an integral biomechanical …

Cell migration through 3D extracellular matrices (ECMs) is crucial to the normal
development of tissues and organs and in disease processes, yet adequate analytical tools …

The ability to replicate in vitro the native extracellular matrix (ECM) features and to control
the three‐dimensional (3D) cell organization plays a fundamental role in obtaining …

Bioprinting is a process of precisely designed scaffolds using three-dimensional printing
technologies for functional tissue engineering utilizing cell-laden biomaterials as bioink. A …

The accurate study of cellular microenvironments is limited by the lack of technologies that
can manipulate cells in 3D at a sufficiently small length scale. The ability to build and …