For many years, stem cell metabolism was viewed as a byproduct of cell fate status rather
than an active regulatory mechanism; however, there is now a growing appreciation that …

Metabolomics is emerging as a powerful tool for studying metabolic processes, identifying
crucial biomarkers responsible for metabolic characteristics and revealing metabolic …

Somatic mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2) contribute to the
pathogenesis of cancer via production of the" oncometabolite" D-2-hydroxyglutarate (D …

The metabolite 2-oxoglutarate (also known as α-ketoglutarate, 2-ketoglutaric acid, or
oxoglutaric acid) lies at the intersection between the carbon and nitrogen metabolic …

In the mouse, naïve pluripotent stem cells (PSCs) are thought to represent the cell culture
equivalent of the late epiblast in the pre-implantation embryo, with which they share a …

Epigenetic mechanisms by which cells inherit information are, to a large extent, enabled by
DNA methylation and posttranslational modifications of histone proteins. These …

Tumor cells able to recapitulate tumor heterogeneity have been tracked, isolated and
characterized in different tumor types, and are commonly named Cancer Stem Cells or …

Otto Warburg discovered that cancer cells exhibit a high rate of glycolysis in the presence of
ample oxygen, a process termed aerobic glycolysis, in 1924 (Warburg et al., 1924). Since …

Aerobic glycolysis has been generally associated with cancer cell proliferation, but
fascinating and novel data show that it is also coupled to a series of further cellular functions …

Although histone H3 lysine 27 trimethylation (H3K27Me3) is associated with gene silencing,
whether H3K27Me3 demethylation affects transcription and cell differentiation in vivo has …