From cardiac tissue engineering to heart-on-a-chip: beating challenges

YS Zhang, J Aleman, A Arneri, S Bersini… - Biomedical …, 2015 - iopscience.iop.org
The heart is one of the most vital organs in the human body, which actively pumps the blood
through the vascular network to supply nutrients to as well as to extract wastes from all other …

Polymers for cell/tissue anti-adhesion

E Lih, SH Oh, YK Joung, JH Lee, DK Han - Progress in polymer science, 2015 - Elsevier
The appropriate anti-adhesive effect of polymers on cells or tissues in the body is one of the
essential requirements of maintaining health and protecting the body from trauma and …

[HTML][HTML] Generation of multicellular tumor spheroids with microwell-based agarose scaffolds for drug testing

X Gong, C Lin, J Cheng, J Su, H Zhao, T Liu, X Wen… - PloS one, 2015 - journals.plos.org
Three dimensional multicellular aggregate, also referred to as cell spheroid or microtissue,
is an indispensable tool for in vitro evaluating antitumor activity and drug efficacy. Compared …

A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity

AE Cerchiari, JC Garbe, NY Jee… - Proceedings of the …, 2015 - National Acad Sciences
Developing tissues contain motile populations of cells that can self-organize into spatially
ordered tissues based on differences in their interfacial surface energies. However, it is …

[HTML][HTML] Control of stem cell fate by engineering their micro and nanoenvironment

MF Griffin, PE Butler, AM Seifalian… - World journal of stem …, 2015 - ncbi.nlm.nih.gov
Stem cells are capable of long-term self-renewal and differentiation into specialised cell
types, making them an ideal candidate for a cell source for regenerative medicine. The …

Nonlinear 3D projection printing of concave hydrogel microstructures for long-term multicellular spheroid and embryoid body culture

KC Hribar, D Finlay, X Ma, X Qu, MG Ondeck… - Lab on a Chip, 2015 - pubs.rsc.org
Long-term culture and monitoring of individual multicellular spheroids and embryoid bodies
(EBs) remains a challenge for in vitro cell propagation. Here, we used a continuous 3D …

Production of uniform 3D microtumors in hydrogel microwell arrays for measurement of viability, morphology, and signaling pathway activation

M Singh, DA Close, S Mukundan… - Assay and drug …, 2015 - liebertpub.com
Despite significant investments in cancer research and drug discovery/development, the rate
of new cancer drug approval is≤ 5% and most cases of metastatic cancer remain incurable …

[PDF][PDF] Organ-on-a-chip platforms for drug delivery and cell characterization: A review

Z Wang, R Samanipour, KI Koo, K Kim - Sens. Mater, 2015 - researchgate.net
Developments in micro-and nanofluidic technologies have led to new kinds of cell culture
and screening systems that are collectively termed organ-on-a-chip systems. Organ-on-a …

Concise review: stem cell microenvironment on a chip: current technologies for tissue engineering and stem cell biology

DY Park, J Lim, JY Park, SH Lee - Stem cells translational …, 2015 - academic.oup.com
Stem cells have huge potential in many therapeutic areas. With conventional cell culture
methods, however, it is difficult to achieve in vivo-like microenvironments in which a number …

Engineering strategies for the formation of embryoid bodies from human pluripotent stem cells

G Pettinato, X Wen, N Zhang - Stem cells and development, 2015 - liebertpub.com
Human pluripotent stem cells (hPSCs) are powerful tools for regenerative therapy and
studying human developmental biology, attributing to their ability to differentiate into many …