[HTML][HTML] Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences

F Coll, R McNerney, MD Preston… - Genome medicine, 2015 - Springer
Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease
control. Current molecular tests examine limited numbers of mutations, and although whole …

Clinical value of whole-genome sequencing of Mycobacterium tuberculosis

HE Takiff, O Feo - The Lancet Infectious Diseases, 2015 - thelancet.com
Whole-genome sequencing (WGS) is now common as a result of new technologies that can
rapidly sequence a complete bacterial genome for US $500 or less. Many studies have …

[HTML][HTML] Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis …

KA Cohen, T Abeel, A Manson McGuire… - PLoS …, 2015 - journals.plos.org
Background The continued advance of antibiotic resistance threatens the treatment and
control of many infectious diseases. This is exemplified by the largest global outbreak of …

[HTML][HTML] Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain

V Eldholm, J Monteserin, A Rieux, B Lopez… - Nature …, 2015 - nature.com
The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB)
pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy …

[HTML][HTML] Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe

GL Kay, MJ Sergeant, Z Zhou, JZM Chan… - Nature …, 2015 - nature.com
Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and
patterns of infection at 'peak TB'relate to what we see today. Here we describe 14 genome …

[HTML][HTML] Population genomics of Mycobacterium tuberculosis in Ethiopia contradicts the virgin soil hypothesis for human tuberculosis in Sub-Saharan Africa

I Comas, E Hailu, T Kiros, S Bekele, W Mekonnen… - Current Biology, 2015 - cell.com
Colonial medical reports claimed that tuberculosis (TB) was largely unknown in Africa prior
to European contact, providing a" virgin soil" for spread of TB in highly susceptible …

Population genomics of Mycobacterium tuberculosis in the Inuit

RS Lee, N Radomski, JF Proulx… - Proceedings of the …, 2015 - National Acad Sciences
Nunavik, Québec suffers from epidemic tuberculosis (TB), with an incidence 50-fold higher
than the Canadian average. Molecular studies in this region have documented limited …

[HTML][HTML] Whole Genome Sequencing Based Characterization of Extensively Drug-Resistant Mycobacterium tuberculosis Isolates from Pakistan

A Ali, Z Hasan, R McNerney, K Mallard… - PloS one, 2015 - journals.plos.org
Improved molecular diagnostic methods for detection drug resistance in Mycobacterium
tuberculosis (MTB) strains are required. Resistance to first-and second-line anti-tuberculous …

The essential role of SepF in mycobacterial division

S Gola, T Munder, S Casonato… - Molecular …, 2015 - Wiley Online Library
Mycobacteria lack several of the components that are essential in model systems as E
scherichia coli or B acillus subtilis for the formation of the divisome, a ring‐like structure …

Enterococcus faecium QU 50: a novel thermophilic lactic acid bacterium for high-yield l-lactic acid production from xylose

MA Abdel-Rahman, Y Tashiro, T Zendo… - FEMS Microbiology …, 2015 - academic.oup.com
The photosynthetic bacterium Rhodobacter sphaeroides and plant pathogenic fungus
Cercospora nicotianae have been used as models for understanding resistance to singlet …