The epigenetics of aging and neurodegeneration
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …
expression that do not involve changes in the genotype. Epigenetics is of increasing …
Histone deacetylase 6 in health and disease
C Seidel, M Schnekenburger, M Dicato… - Epigenomics, 2015 - Taylor & Francis
Histone deacetylase (HDAC) 6 is a member of the class IIb HDAC family. This enzyme is
zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with …
zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with …
Acylation of biomolecules in prokaryotes: a widespread strategy for the control of biological function and metabolic stress
KL Hentchel… - … and Molecular Biology …, 2015 - Am Soc Microbiol
Acylation of biomolecules (eg, proteins and small molecules) is a process that occurs in cells
of all domains of life and has emerged as a critical mechanism for the control of many …
of all domains of life and has emerged as a critical mechanism for the control of many …
Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo
JM Gajer, SD Furdas, A Gründer, M Gothwal… - Oncogenesis, 2015 - nature.com
We have previously described novel histone acetyltransferase (HAT) inhibitors that block
neuroblastoma cell growth in vitro. Here we show that two selected pyridoisothiazolone HAT …
neuroblastoma cell growth in vitro. Here we show that two selected pyridoisothiazolone HAT …
DDIT3 and KAT2A proteins regulate TNFRSF10A and TNFRSF10B expression in endoplasmic reticulum stress-mediated apoptosis in human lung cancer cells
TNFRSF10A and TNFRSF10B are cell surface receptors that bind to tumor necrosis factor-
related apoptosis-inducing ligand (TRAIL) and mediate the extrinsic pathway of apoptosis …
related apoptosis-inducing ligand (TRAIL) and mediate the extrinsic pathway of apoptosis …
Fetal iron deficiency induces chromatin remodeling at the Bdnf locus in adult rat hippocampus
PV Tran, BC Kennedy, YC Lien… - American Journal …, 2015 - journals.physiology.org
Fetal and subsequent early postnatal iron deficiency causes persistent impairments in
cognitive and affective behaviors despite prompt postnatal iron repletion. The long-term …
cognitive and affective behaviors despite prompt postnatal iron repletion. The long-term …
[HTML][HTML] The histone acetyltransferase GCN5 expression is elevated and regulated by c-Myc and E2F1 transcription factors in human colon cancer
YW Yin, HJ Jin, W Zhao, B Gao, J Fang, J Wei… - Gene …, 2015 - ncbi.nlm.nih.gov
The histone acetyltransferase GCN5 has been suggested to be involved in promoting
cancer cell growth. But its role in human colon cancer development remains unknown …
cancer cell growth. But its role in human colon cancer development remains unknown …
Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization
L Zhao, Y Wang, D Cao, T Chen, Q Wang… - Journal of Medicinal …, 2015 - ACS Publications
The signal transduction of acetylated histone can be processed through a recognition
module, bromodomain. Several inhibitors targeting BRD4, one of the bromodomain …
module, bromodomain. Several inhibitors targeting BRD4, one of the bromodomain …
Modulation of immune responses by histone deacetylase inhibitors
S Schotterl, H Brennenstuhl… - Critical Reviews™ in …, 2015 - dl.begellhouse.com
Recent studies have demonstrated that histone deacetylase (HDAC) inhibitors (HDACi)
have potential immunomodulatory activity since they affect the immune surveillance by …
have potential immunomodulatory activity since they affect the immune surveillance by …
Epigenetic studies of suicidal behavior
A Bani-Fatemi, AS Howe, V De Luca - Neurocase, 2015 - Taylor & Francis
Recent studies have shown an association between gene alterations by epigenetic
mechanisms and suicidal behavior. These epigenetic mechanisms are mitotically, and in …
mechanisms and suicidal behavior. These epigenetic mechanisms are mitotically, and in …