Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Histone deacetylase (HDAC) 6 is a member of the class IIb HDAC family. This enzyme is
zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with …

Acylation of biomolecules (eg, proteins and small molecules) is a process that occurs in cells
of all domains of life and has emerged as a critical mechanism for the control of many …

We have previously described novel histone acetyltransferase (HAT) inhibitors that block
neuroblastoma cell growth in vitro. Here we show that two selected pyridoisothiazolone HAT …

TNFRSF10A and TNFRSF10B are cell surface receptors that bind to tumor necrosis factor-
related apoptosis-inducing ligand (TRAIL) and mediate the extrinsic pathway of apoptosis …

Fetal and subsequent early postnatal iron deficiency causes persistent impairments in
cognitive and affective behaviors despite prompt postnatal iron repletion. The long-term …

The histone acetyltransferase GCN5 has been suggested to be involved in promoting
cancer cell growth. But its role in human colon cancer development remains unknown …

The signal transduction of acetylated histone can be processed through a recognition
module, bromodomain. Several inhibitors targeting BRD4, one of the bromodomain …

Recent studies have demonstrated that histone deacetylase (HDAC) inhibitors (HDACi)
have potential immunomodulatory activity since they affect the immune surveillance by …

Recent studies have shown an association between gene alterations by epigenetic
mechanisms and suicidal behavior. These epigenetic mechanisms are mitotically, and in …