AIM: To evaluate the effect of orally administered plecanatide or dolcanatide, analogs of
uroguanylin, on amelioration of colitis in murine models. METHODS: The cyclic guanosine …

Gut homeostasis plays an important role in maintaining the overall body health during aging.
Rapamycin, a specific inhibitor of mTOR, exerts prolongevity effects in evolutionarily diverse …

Objective. Activation of membrane receptor guanylate cyclase-C (GC-C) is implicated in
gastrointestinal fluid and electrolyte balance, preservation of intestinal barrier integrity, anti …

The gastrointestinal tract, due to its role as a digestive organ and as a barrier between the
exterior and interior milieus, is critically impacted by dietary, environmental, and …

Introduction: Inflammatory bowel disease (IBD) consists of Crohn's disease, ulcerative colitis
and an unspecific IBD. The unclear etiology of IBD is a limiting factor that complicates the …

Linaclotide, a synthetic guanylyl cyclase C (GC‐C) agonist, and the prostone analog,
Lubiprostone, are approved to manage chronic idiopathic constipation and constipation …