Over the last decade, a piece of the research studying copper role in biological systems was
devoted to unravelling a still elusive, but extremely intriguing, aspect that is the involvement …

Parkinson's disease (PD) is the most frequent neurodegenerative movement disorder with
severe consequences for patients and caregivers. In the last twenty years of research, alpha …

Copper ions are indispensible to life and maintaining tight control over the homeostasis of
copper ions in the body is a prerequisite to sustaining health. Aberrations in normal copper …

Gold nanoparticles (Au NPs) have attracted much attention due to their potential
applications in nanomedicine. While numerous studies have quantified biomolecular …

Growing evidence supports a link between brain copper homeostasis, the formation of alpha-
synuclein (AS)-copper complexes, and the development of Parkinson disease (PD) …

Gene multiplications or point mutations in alpha (α)-synuclein are associated with familial
and sporadic Parkinson's disease (PD). An increase in copper (Cu) levels has been …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the presence of
abnormal α-synuclein (αSyn) deposits in the brain. Alterations in metal homeostasis and …

Parkinson's disease (PD) etiology is closely linked to the aggregation of α-synuclein (αS).
Copper (II) ions can bind to αS and may impact its aggregation propensity. As a …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the presence of
abnormal α-synuclein (αS) deposits in the brain. Alterations in homeostasis and metal …

Pathologies of neurological diseases are increasingly recognized to have common
structural and molecular events that can fit, sometimes loosely, into a central pathological …