Clinical development of curcumin in neurodegenerative disease

S Hu, P Maiti, Q Ma, X Zuo, MR Jones… - Expert review of …, 2015 - Taylor & Francis
Curcumin, a polyphenolic antioxidant derived from the turmeric root has undergone
extensive preclinical development, showing remarkable efficacy in wound repair, cancer …

Heterologous production of curcuminoids

JL Rodrigues, KLJ Prather, LD Kluskens… - Microbiology and …, 2015 - Am Soc Microbiol
Curcuminoids, components of the rhizome of turmeric, show several beneficial biological
activities, including anticarcinogenic, antioxidant, anti-inflammatory, and antitumor activities …

Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)

KK Cheng, PS Chan, S Fan, SM Kwan, KL Yeung… - Biomaterials, 2015 - Elsevier
Diagnosis of Alzheimer's disease (AD) can be performed with the assistance of amyloid
imaging. The current method relies on positron emission tomography (PET), which is …

Novel curcumin-loaded gel-core hyaluosomes with promising burn-wound healing potential: development, in-vitro appraisal and in-vivo studies

WM El-Refaie, YSR Elnaggar, MA El-Massik… - International journal of …, 2015 - Elsevier
Despite its effectiveness, curcumin (Curc) dermal delivery is handicapped by hydrophobicity,
high metabolism and poor skin permeation. In this work, the potential of novel self …

[HTML][HTML] Synthesis and evaluation of the anti-oxidant capacity of curcumin glucuronides, the major curcumin metabolites

AK Choudhury, S Raja, S Mahapatra… - Antioxidants, 2015 - mdpi.com
Curcumin metabolites namely curcumin monoglucuronide and curcumin diglucuronide were
synthesized using an alternative synthetic approach. The anti-oxidant potential of these …

Recent advances in molecular imaging probes for β-amyloid plaques

M Ono, H Saji - MedChemComm, 2015 - pubs.rsc.org
In this review, we introduce recent advances in our development of molecular imaging
probes for positron emission tomography (PET), single photon emission computed …

[HTML][HTML] Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in …

SKS Sarada, M Titto, P Himadri, S Saumya… - Journal of …, 2015 - Springer
Background The present study was proposed to elucidate the prophylactic role of curcumin
in the prevention of hypoxia-induced cerebral edema (HACE). Methods Rats were exposed …

Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer's disease

R McClure, D Yanagisawa, D Stec… - Journal of …, 2015 - content.iospress.com
Curcumin is a promising compound that can be used as a theranostic agent to aid research
in Alzheimer's disease. Beyond its ability to bind to amyloid plaques, the compound can also …

Insights into the Interaction Mechanism of Ligands with Aβ42 Based on Molecular Dynamics Simulations and Mechanics: Implications of Role of Common Binding …

HS Kundaikar, MS Degani - Chemical biology & drug design, 2015 - Wiley Online Library
Aggregation of β‐amyloid (Aβ) into oligomers and further into fibrils is hypothesized to be a
key factor in pathology of Alzheimer's disease (AD). In this study, mapping and docking were …

Bioavailable curcuminoid formulations for treating alzheimer's disease and other age-related disorders

SA Frautschy, GM Cole - US Patent 9,192,644, 2015 - Google Patents
Curcuminoid formulations having enhanced bioavailability are provided and comprise a
curcuminoid, antioxidant, glucuronidation inhibitor, and water-soluble, pharmaceutically …