Clinical development of curcumin in neurodegenerative disease
S Hu, P Maiti, Q Ma, X Zuo, MR Jones… - Expert review of …, 2015 - Taylor & Francis
Curcumin, a polyphenolic antioxidant derived from the turmeric root has undergone
extensive preclinical development, showing remarkable efficacy in wound repair, cancer …
extensive preclinical development, showing remarkable efficacy in wound repair, cancer …
Heterologous production of curcuminoids
JL Rodrigues, KLJ Prather, LD Kluskens… - Microbiology and …, 2015 - Am Soc Microbiol
Curcuminoids, components of the rhizome of turmeric, show several beneficial biological
activities, including anticarcinogenic, antioxidant, anti-inflammatory, and antitumor activities …
activities, including anticarcinogenic, antioxidant, anti-inflammatory, and antitumor activities …
Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)
Diagnosis of Alzheimer's disease (AD) can be performed with the assistance of amyloid
imaging. The current method relies on positron emission tomography (PET), which is …
imaging. The current method relies on positron emission tomography (PET), which is …
Novel curcumin-loaded gel-core hyaluosomes with promising burn-wound healing potential: development, in-vitro appraisal and in-vivo studies
Despite its effectiveness, curcumin (Curc) dermal delivery is handicapped by hydrophobicity,
high metabolism and poor skin permeation. In this work, the potential of novel self …
high metabolism and poor skin permeation. In this work, the potential of novel self …
[HTML][HTML] Synthesis and evaluation of the anti-oxidant capacity of curcumin glucuronides, the major curcumin metabolites
AK Choudhury, S Raja, S Mahapatra… - Antioxidants, 2015 - mdpi.com
Curcumin metabolites namely curcumin monoglucuronide and curcumin diglucuronide were
synthesized using an alternative synthetic approach. The anti-oxidant potential of these …
synthesized using an alternative synthetic approach. The anti-oxidant potential of these …
Recent advances in molecular imaging probes for β-amyloid plaques
M Ono, H Saji - MedChemComm, 2015 - pubs.rsc.org
In this review, we introduce recent advances in our development of molecular imaging
probes for positron emission tomography (PET), single photon emission computed …
probes for positron emission tomography (PET), single photon emission computed …
[HTML][HTML] Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in …
SKS Sarada, M Titto, P Himadri, S Saumya… - Journal of …, 2015 - Springer
Background The present study was proposed to elucidate the prophylactic role of curcumin
in the prevention of hypoxia-induced cerebral edema (HACE). Methods Rats were exposed …
in the prevention of hypoxia-induced cerebral edema (HACE). Methods Rats were exposed …
Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer's disease
R McClure, D Yanagisawa, D Stec… - Journal of …, 2015 - content.iospress.com
Curcumin is a promising compound that can be used as a theranostic agent to aid research
in Alzheimer's disease. Beyond its ability to bind to amyloid plaques, the compound can also …
in Alzheimer's disease. Beyond its ability to bind to amyloid plaques, the compound can also …
Insights into the Interaction Mechanism of Ligands with Aβ42 Based on Molecular Dynamics Simulations and Mechanics: Implications of Role of Common Binding …
HS Kundaikar, MS Degani - Chemical biology & drug design, 2015 - Wiley Online Library
Aggregation of β‐amyloid (Aβ) into oligomers and further into fibrils is hypothesized to be a
key factor in pathology of Alzheimer's disease (AD). In this study, mapping and docking were …
key factor in pathology of Alzheimer's disease (AD). In this study, mapping and docking were …
Bioavailable curcuminoid formulations for treating alzheimer's disease and other age-related disorders
SA Frautschy, GM Cole - US Patent 9,192,644, 2015 - Google Patents
Curcuminoid formulations having enhanced bioavailability are provided and comprise a
curcuminoid, antioxidant, glucuronidation inhibitor, and water-soluble, pharmaceutically …
curcuminoid, antioxidant, glucuronidation inhibitor, and water-soluble, pharmaceutically …