The present advances in biology are related to progress in genomics, proteomics, and other
“-omics”, including glycomics, working with a large amount of data regarding human and …

Parkinson's Disease (PD) is a complex neurodegenerative disorder classically
characterized by movement impairment. Pathologically, the most striking features of PD are …

Abstract α-Synuclein (α-syn) is a 140-residue intrinsically disordered protein that is involved
in neuronal and synaptic vesicle plasticity, but its aggregation to form amyloid fibrils is the …

α-Synuclein oligomers can be toxic to cells and may be responsible for cell death in
Parkinson's disease. Their typically low abundance and highly heterogeneous nature …

In this work, we investigated the inhibitory ability of taurine on the aggregation of Human
serum albumin (HSA) and also examined how it controls the kinetic parameters of the …

The conversion of α-synuclein from its intrinsically disordered monomeric state into the
fibrillar cross-β aggregates characteristically present in Lewy bodies is largely unknown. The …

Background: Little is known about the effect of PD-linked mutations on α-synuclein (α-syn)
phosphorylation. Results: The E46K mutation increases α-syn phosphorylation at Ser-129 …

Neurodegenerative disorders associated with protein misfolding are fatal diseases that are
caused by fibrillation of endogenous proteins such as α-synuclein (α-syn) in Parkinson's …

Misfolding and aggregation of α-synuclein into toxic soluble oligomeric α-synuclein
aggregates has been strongly correlated with the pathogenesis of Parkinson's disease (PD) …

The Saccharomyces cerevisiae heat shock protein Hsp31 is a stress-inducible homodimeric
protein that is involved in diauxic shift reprogramming and has glyoxalase activity. We show …