Rituximab in autoimmune thrombotic thrombocytopenic purpura: a success story

A Froissart, A Veyradier, M Hié, Y Benhamou… - European Journal of …, 2015 - Elsevier
Despite a significant improvement of thrombotic thrombocytopenic purpura (TTP) prognosis
since the use of plasma exchange, morbidity and mortality remained significant because of …

The complex differential diagnosis between thrombotic thrombocytopenic purpura and the atypical hemolytic uremic syndrome: Laboratory weapons and their impact …

PM Mannucci, M Cugno - Thrombosis research, 2015 - Elsevier
Thrombocytopenia and microangiopathic hemolytic anemia are the hallmark of the
thrombotic microangiopathies (TMAs) thrombotic thrombocytopenic purpura (TTP) and …

What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura

JE Sadler - Hematology 2014, the American Society of …, 2015 - ashpublications.org
Severe ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif,
member 13) deficiency causes thrombotic thrombocytopenic purpura (TTP), which is …

[HTML][HTML] Guía diagnóstica y terapéutica de las microangiopatías trombóticas del Grupo Español de Aféresis

E Contreras, J de la Rubia, J del Río-Garma… - Medicina Clínica, 2015 - Elsevier
Las microangiopatías trombóticas (MAT) son un grupo de entidades que se caracterizan por
presentar una anemia hemolítica microangiopática (con los típicos esquistocitos en el frotis …

Diagnostic and therapeutic guidelines of thrombotic microangiopathies of the Spanish Apheresis Group

E Contreras, J de la Rubia, J del Río-Garma… - … Clínica (English Edition), 2015 - Elsevier
Thrombotic microangiopathies (TMA) are disorders defined by the presence of a
microangiopathic hemolytic anaemia (with the characteristic hallmark of schistocytes in the …

[HTML][HTML] Neutralization of inhibitory antibodies and restoration of therapeutic ADAMTS‐13 activity levels in inhibitor‐treated rats by the use of defined doses of …

B Plaimauer, A Schiviz, S Kaufmann, W Höllriegl… - Journal of Thrombosis …, 2015 - Elsevier
Background Acquired thrombotic thrombocytopenic purpura (TTP) is caused by an
autoantibody‐mediated deficiency of the von Willebrand factor‐cleaving protease ADAMTS …

Thrombotic thrombocytopenic purpura: from diagnosis to therapy

E Mariotte, A Veyradier - Current opinion in critical care, 2015 - journals.lww.com
The classification of thrombotic microangiopathies has evolved from a clinical to a
pathophysiological definition. TTP is characterized by a severe ADAMTS13 deficiency that …

Reduced ADAMTS13 activity is associated with thrombotic risk in systemic lupus erythematosus

S Martin-Rodriguez, JC Reverter, D Tàssies… - Lupus, 2015 - journals.sagepub.com
Background: Severe deficiency of ADAMTS13 activity leads to von Willebrand factor (VWF)
ultralarge multimers with high affinity for platelets, causing thrombotic thrombocytopenic …

Understanding organ dysfunction in thrombotic thrombocytopenic purpura

PM Mannucci - Intensive care medicine, 2015 - Springer
Thrombotic thrombocytopenic purpura (TTP) is the epitome of thrombotic microangiopathies
(TMA), ie, rare multisystem diseases characterized by disseminated microvascular …

[PDF][PDF] Post-partum management in a patient affected by thrombotic thrombocytopenic purpura: case report and review of literature

AS Lagana, V Sofo, FM Salmeri… - Clin Exp …, 2015 - venus-pro-bucket.s3.amazonaws …
Thrombotic thrombocytopenic purpura (TTP) is a rare and potentially lethal syndrome
characterized by severe thrombocytopenia, microangiopathic haemolytic anaemia, and …