Healthy kidneys maintain fluid and electrolyte homoeostasis by adjusting urine volume and
composition according to physiological needs. The final urine composition is determined in …

Intercalated cells are kidney tubule epithelial cells with important roles in the regulation of
acid-base homeostasis. However, in recent years the understanding of the function of the …

Abstract P2Y 12 receptor (P2Y 12-R) signaling is mediated through G i, ultimately reducing
cellular cAMP levels. Because cAMP is a central modulator of arginine vasopressin (AVP) …

Abstract Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant disorder. Lithium is
able to stimulate autophagy, and to reduce Ca 2+ efflux from the inositol-1, 4, 5-triphosphate …

Lithium is an important medication in the treatment of mood disorders. However, clinicians
are hesitant to use lithium in older adults for fear of its medical effects, particularly kidney …

Dicer is a crucial enzyme for the maturation of miRNAs. Mutations in the Dicer gene are
highly associated with Pleuro Pulmonary Blastoma-Family Dysplasia Syndrome (PPB-FDS …

In mammals, glycogen synthase kinase (GSK) 3 comprises GSK3α and GSK3β isoforms.
GSK3β has been shown to play a role in the ability of kidneys to concentrate urine by …

Objective To review the relationship between lithium-related renal dysfunction and
microcysts. Method Electronic databases (PubMed and Google Scholar) were queried …

Die Pathogenese ist unklar. Es gibt Hinweise, dass ein modifiziertes C-reaktives Protein
(mCRP) das Zielantigen sowohl in der Uvea als auch in den Tubuluszellen darstellt [46] …

1. Licht RW: Lithium: still a major option in the management of bipolar disorder. CNS
Neurosci Ther 18: 219, 2012.[PMID: 22070642] 2. Malhi GS, Tanious M, Das P, Berk M: The …