Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …

Importance Nonalcoholic fatty liver disease and its subtype nonalcoholic steatohepatitis
affect approximately 30% and 5%, respectively, of the US population. In patients with …

Nonalcoholic fatty liver disease (NAFLD) is a disorder characterized by excess accumulation
of fat in hepatocytes (nonalcoholic fatty liver (NAFL)); in up to 40% of individuals, there are …

Reversibility of hepatic fibrosis and cirrhosis following antiviral therapy for hepatitis B or C
has advanced the prospect of developing antifibrotic therapies for patients with chronic liver …

Understanding the molecular mechanisms underlying liver fibrogenesis is fundamentally
relevant to developing new treatments that are independent of the underlying etiology. The …

An improved understanding of non-alcoholic fatty liver disease epidemiology would lead to
identification of individuals at high risk of developing chronic liver disease and extra-hepatic …

The composition of the bile acid pool is a function of the microbial metabolism of bile acids in
the intestine. Perturbations of the microbiota shape the bile acid pool and modulate the …

Hepatic steatosis is defined as intrahepatic fat of at least 5% of liver weight. Simple
accumulation of triacylglycerols in the liver could be hepatoprotective; however, prolonged …

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of abnormal serum
aminotransferase levels in both developed and developing countries. Patients with …

Background and aims Non-alcoholic steatohepatitis (NASH), the potentially progressive
form of nonalcoholic fatty liver disease (NAFLD), is the pandemic liver disease of our time …