AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer
D Hong, R Kurzrock, Y Kim, R Woessner… - Science translational …, 2015 - science.org
Next-generation sequencing technologies have greatly expanded our understanding of
cancer genetics. Antisense technology is an attractive platform with the potential to translate …
cancer genetics. Antisense technology is an attractive platform with the potential to translate …
Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN
J Grisouard, T Shimizu, A Duek… - Blood, The Journal …, 2015 - ashpublications.org
The acquired somatic JAK2-V617F mutation is present in> 80% of patients with
myeloproliferative neoplasms (MPNs). Stat3 plays a role in hematopoietic homeostasis and …
myeloproliferative neoplasms (MPNs). Stat3 plays a role in hematopoietic homeostasis and …
Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after …
A Schumacher, B Denecke, T Braunschweig… - Journal of Hematology & …, 2015 - Springer
Background Upon inflammation, myeloid cell generation in the bone marrow (BM) is broadly
enhanced by the action of induced cytokines which are produced locally and at multiple …
enhanced by the action of induced cytokines which are produced locally and at multiple …
BCR-ABL negative myeloproliferative neoplasia: a review of involved molecular mechanisms
SM Koopmans, HC Schouten, AMW van Mario - 2015 - digitum.um.es
The clonal bone marrow stem cell disorders essential thrombocythemia (ET), polycythemia
vera (PV) and primary myelofibrosis (PMF) belong to the group of Philadelphia chromosome …
vera (PV) and primary myelofibrosis (PMF) belong to the group of Philadelphia chromosome …
Divergent regulations of c-Kit receptor by TPO and CD9 in megakaryocytic cells: implication in the dynamic control of the balance proliferation/differentiation
A Chaabouni - 2015 - theses.hal.science
The Thrombopoietin (TPO) favors both the proliferation and the maturation of
megakaryocytic progenitors, raising the question of the molecular mechanism explaining its …
megakaryocytic progenitors, raising the question of the molecular mechanism explaining its …