We have become increasingly aware that, during infection, pathogenic bacteria often grow
in multicellular biofilms that are often highly resistant to antibacterial strategies. In order to …

A dental biofilm forms a distinct environment where microorganisms live in a matrix of
extracellular polysaccharides. The biofilm favors certain bacteria and creates a habitat that …

Objective Early childhood caries (ECC) has become a prevalent public health problem
among Chinese preschool children. The bacterial microflora is considered to be an …

Objectives Secondary caries is the most common reason for composite restoration
replacement and usually forms between dentin and the filling. The objective of this study …

Background The etiology of dental caries is multifactorial, but frequent consumption of free
sugars, notably sucrose, appears to be a major factor driving the supragingival microbiota in …

Peri-implantitis is an inflammatory disease that results in the destruction of soft tissue and
bone around the implant. Titanium implant corrosion has been attributed to the implant …

环二鸟苷酸(cyclic diguanylate, c-di-GMP) 是细菌中存在的众多信使分子之一,
参与调节多种生理功能, 包括细菌的信号传递, 内外环境调理, 生物被膜形成等 …

Periodontal disease (PD) is a multifactorial disease of the oral cavity affecting the majority of
the population. Although not a direct cause of mortality, PD is a health concern because it …