Lymphocytes must adapt to a wide array of environmental stressors as part of their normal
development, during which they undergo a dramatic metabolic remodeling process …

Defects in autophagy have been linked to a wide range of medical illnesses, including
cancer as well as infectious, neurodegenerative, inflammatory, and metabolic diseases …

Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor
responses in hematologic malignancies, but tumor regression has rarely occurred using …

During activation, T cells undergo metabolic reprogramming, which imprints distinct
functional fates. We determined that on PD-1 ligation, activated T cells are unable to engage …

Metformin, a prescribed drug for type 2 diabetes, has been reported to have anti-cancer
effects; however, the underlying mechanism is poorly understood. Here we show that this …

Activation of mTOR-dependent pathways regulates the specification and differentiation of
CD4+ T effector cell subsets. Herein, we show that mTOR complex 1 (mTORC1) and …

Current treatments to control pathological or unwanted immune responses often use broadly
immunosuppressive drugs. New approaches to induce antigen-specific immunological …

The specific regulation of cellular metabolic processes is of major importance for directing
immune cell differentiation and function. We review recent evidence indicating that changes …

Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) results in
complete regression of advanced cancer in some patients, but the efficacy of this potentially …

The differentiation of CD4+ helper T cell subsets with diverse effector functions is
accompanied by changes in metabolism required to meet their bioenergetic demands. We …