Reduction-oxidation or “redox” reactions are an integral part of a broad range of cellular
processes such as gene expression, energy metabolism, protein import and folding, and …

Peroxisomal and mitochondrial malfunction, which are highly intertwined through redox
regulation, in combination with defective proteostasis, are hallmarks of the most prevalent …

Pioglitazone is currently undergoing clinical trials for treatment of Alzheimer's disease (AD).
However, poor brain penetration remains an obstacle to development of the drug for such …

Abstract X‐linked Adrenoleukodystrophy (X‐ALD), an inherited peroxisomal metabolic
neurodegenerative disorder, is caused by mutations/deletions in the ATP‐binding cassette …

Abstract X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder
resulting from defective ABCD1 transport protein. ABCD1 mediates peroxisomal uptake of …

Abstract X-linked adrenoleukodystrophy (X-ALD) is a rare neurometabolic disease
characterized by the accumulation of very long chain fatty acids (VLCFAs) due to a loss of …

X-linked adrenomyeloneuropathy (AMN) is an inherited neurometabolic disorder caused by
malfunction of the ABCD1 gene, characterized by slowly progressing spastic paraplegia …

Oxidative stress and mitochondrial failure are prominent factors in the axonal degeneration
process. In this study, we demonstrate that sirtuin 1 (SIRT1), a key regulator of the …

Methotrexate (MTX) is widely used in treatment of cancers and autoimmune diseases.
However, nephrotoxicity is one of its most important side effects. The peroxisome proliferator …

Neurodegenerative diseases are characterized by a gradual and selective loss of neurons.
ROS overload has been proved to occur early in this heterogeneous group of disorders …