Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron
donor in all organisms. It provides the reducing power that drives numerous anabolic …

The metabolite 2-oxoglutarate (also known as α-ketoglutarate, 2-ketoglutaric acid, or
oxoglutaric acid) lies at the intersection between the carbon and nitrogen metabolic …

Monascus has been used to produce natural colorants and food supplements for more than
one thousand years and approximately more than one billion people eat Monascus …

Evolutionary innovations that enable organisms to colonize new ecological niches are rare
compared to gradual evolutionary changes in existing traits. We discovered that key …

In this review, we examine how bacterial metabolism is shaped by chemical constraints
acting on the material and dynamic layout of enzymatic networks and beyond. These are …

Carbon dioxide formation mirrors the final carbon oxidation steps of aerobic metabolism in
microbial and mammalian cells. As a consequence, CO 2/HCO 3− dissociation equilibria …

Marine bacteria form one of the largest living surfaces on Earth, and their metabolic activity
is of fundamental importance for global nutrient cycling. Here, we explored the largely …

Using methanol as an alternative non-food feedstock for biotechnological production offers
several advantages in line with a methanol-based bioeconomy. The Gram-positive …

Protein investment costs are considered a major driver for the choice of alternative metabolic
strategies. We tested this premise in L actococcus lactis, a bacterium that exhibits a distinct …

The review describes efforts toward metabolic engineering of production of organic acids.
One aspect of the strategy involves the generation of an appropriate amount and type of …