Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine
function, metabolism, immune function and other systems through its effects on the central …

The global rise in the prevalence of obesity and associated co-morbidities such as type 2
diabetes, cardiovascular disease, and cancer represents a major public health concern. The …

Leptin is not able to treat typical obesity; however, it is effective for reversing leptin deficiency-
induced obesity and is possibly useful in lipodystrophy. New mechanisms and pathways …

Leptin was initially best known for its role in energy homeostasis and regulation of energy
expenditure. In the past few years we have realized that leptin also plays a major role in …

Adipose tissue is recognized as an active endocrine organ that produces a number of
endocrine substances referred to as “adipokines” including leptin, adiponectin, adipolin …

Leptin has key roles in the regulation of energy balance, body weight, metabolism, and
endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy …

Mutations in the gene encoding leptin (LEP) typically lead to an absence of circulating leptin
and to extreme obesity. We describe a 2-year-old boy with early-onset extreme obesity due …

Recent insights into the neural circuits controlling energy balance and glucose homeostasis
have rekindled the hope for development of novel treatments for obesity and diabetes …

Receptors of leptin, the prototypical adipokine, are expressed throughout the cortex and
several other areas of the brain. Although typically studied for its role in energy intake and …

The adipose hormone leptin potently influences physical activity. Leptin can decrease
locomotion and running, yet the mechanisms involved and the influence of leptin on the …