Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family originally described
as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is …

An increasing proportion of the worldwide population is affected by allergic diseases such
as allergic rhinitis (AR), atopic dermatitis (AD) and allergic asthma and improved treatment …

The convergence of two rapidly developing technologies-high-throughput genotyping and
electronic health records (EHRs)-gives scientists an unprecedented opportunity to utilize …

Systems biology is an approach to understanding living systems that focuses on modeling
diverse types of high-dimensional interactions to develop a more comprehensive …

Inflammation is a key feature of atherosclerosis and its clinical manifestations. The leukocyte
count has emerged as a marker of inflammation that is widely available in clinical practice …

Abstract Interleukin-33 (IL-33) is a recently discovered cytokine that belongs to the IL-1
superfamily and acts as an important regulator in several allergic disorders. It is considered …

Objective To use high‐density genotyping to investigate the genetic associations of acute
anterior uveitis (AAU) in patients with and those without ankylosing spondylitis (AS) …

Eosinophilic esophagitis (EoE) was historically distinguished from gastroesophageal reflux
disease on the basis of histology and lack of responsiveness to acid suppressive therapy …

The cysteine protease caspase-1 (Casp-1) contributes to innate immunity through the
assembly of NLRP3, NLRC4, AIM2, and NLRP6 inflammasomes. Here we ask whether …

IL‐33 released from damaged cells plays a central role in allergic inflammation by acting
through its membrane‐bound receptor, ST2 receptor (ST2L). IL‐33 activity can be …