Investigational agents for treatment of traumatic brain injury
Y Xiong, Y Zhang, A Mahmood… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Traumatic brain injury (TBI) is a major cause of death and disability worldwide.
To date, there are no pharmacologic agents proven to improve outcomes from TBI because …
To date, there are no pharmacologic agents proven to improve outcomes from TBI because …
[HTML][HTML] Static and dynamic factors promoting resilience following traumatic brain injury: a brief review
JN Holland, AT Schmidt - Neural plasticity, 2015 - hindawi.com
Traumatic brain injury (TBI) is the greatest contributing cause of death and disability among
children and young adults in the United States. The current paper briefly summarizes …
children and young adults in the United States. The current paper briefly summarizes …
Is genistein neuroprotective in traumatic brain injury?
The concerns about negative consequences of estrogen therapy have led to introduce other
strategies to obtain estrogen's benefits in the brain. The present study tests the hypothesis …
strategies to obtain estrogen's benefits in the brain. The present study tests the hypothesis …
[HTML][HTML] Estrogen provides neuroprotection against brain edema and blood brain barrier disruption through both estrogen receptors α and β following traumatic brain …
Objective (s): Estrogen (E2) has neuroprotective effects on blood-brain-barrier (BBB) after
traumatic brain injury (TBI). In order to investigate the roles of estrogen receptors (ERs) in …
traumatic brain injury (TBI). In order to investigate the roles of estrogen receptors (ERs) in …
Correlation of brain levels of progesterone and dehydroepiandrosterone with neurological recovery after traumatic brain injury in female mice
AB Lopez-Rodriguez, E Acaz-Fonseca, S Giatti… - …, 2015 - Elsevier
Traumatic brain injury (TBI) is an important cause of disability in humans. Neuroactive
steroids, such as progesterone and dehydroepiandrosterone (DHEA), are neuroprotective in …
steroids, such as progesterone and dehydroepiandrosterone (DHEA), are neuroprotective in …
The brain cytokine levels are modulated by estrogen following traumatic brain injury: Which estrogen receptor serves as modulator?
The present study was designed to explore whether administration of estrogen affects brain
cytokine levels in TBI. We also sought determine which one of type of classical estrogen …
cytokine levels in TBI. We also sought determine which one of type of classical estrogen …
Changes in the gene expression of estrogen receptors involved in the protective effect of estrogen in rat׳ s trumatic brain injury
M Khaksari, Z Hajializadeh, N Shahrokhi… - Brain research, 2015 - Elsevier
It has been demonstrated that estradiol has neuroprotective effects after traumatic brain
injury (TBI) in female rats. Since estrogen receptors have an important role in estradiol …
injury (TBI) in female rats. Since estrogen receptors have an important role in estradiol …
Progesterone alleviates acute brain injury via reducing apoptosis and oxidative stress in a rat experimental subarachnoid hemorrhage model
J Cai, S Cao, J Chen, F Yan, G Chen, Y Dai - Neuroscience letters, 2015 - Elsevier
This study aimed to investigate the therapeutic effect of progesterone on acute brain injury
after subarachnoid hemorrhage (SAH). Subarachnoid hemorrhage was induced in male …
after subarachnoid hemorrhage (SAH). Subarachnoid hemorrhage was induced in male …
Progesterone for neuroprotection in pediatric traumatic brain injury
CL Robertson, E Fidan, RM Stanley… - Pediatric Critical Care …, 2015 - journals.lww.com
Objective: To provide an overview of the preclinical literature on progesterone for
neuroprotection after traumatic brain injury and to describe unique features of …
neuroprotection after traumatic brain injury and to describe unique features of …
[HTML][HTML] Neurosteroids and traumatic brain injury: translating biomarkers to therapeutics; overview and pilot investigations in Iraq and Afghanistan era veterans
Neurosteroids are endogenous molecules that are enriched in the brain (where they can be
synthesized de novo from cholesterol) and also produced in the adrenals, gonads, and other …
synthesized de novo from cholesterol) and also produced in the adrenals, gonads, and other …