Over the last ten years, there has been considerable research interest in the development of
polymeric carriers for biomedicine. Such delivery systems have the potential to significantly …

Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for
metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis …

NMR signal amplification by reversible exchange (SABRE) is a NMR hyperpolarization
technique that enables nuclear spin polarization enhancement of molecules via concurrent …

The combination of a chemotherapeutic drug with a P-glycoprotein (P-gp) inhibitor has
emerged as a promising strategy for treating multidrug resistance (MDR) cancer. To ensure …

Cancers progress through a series of events that can be characterized as “somatic
evolution.” A central premise of Darwinian evolutionary theory is that the environment …

Abstract Cyclic RGDyK (cRGDyK)-conjugated pH-sensitive polymeric micelles were
fabricated for targeted delivery of paclitaxel to prostate cancer cells based on pH-sensitive …

Several diseases, such as cancer, are characterized by acidification of the extracellular
environment. Acidosis can be employed as a target to specifically direct therapies to the …

The cytotoxicity of chemotherapeutic agents to healthy organs and drug resistance of tumor
cells are believed to be the main obstacles to the successful cancer chemotherapy in the …

Alterations in mucin expression and glycosylation are associated with cancer development.
Underglycosylated mucin-1 (uMUC1) is overexpressed in most malignant adenocarcinomas …

To realize a fast and selective capture of nano drug vehicles (NDVs) by malignant tumors,
an instant affinity switchable NDV based on pH-sensitive surface protonation was prepared …