The amyloid cascade hypothesis for the pathogenesis of Alzheimer's disease (AD) was
proposed over twenty years ago. However, the mechanisms of neurodegeneration and …

Mitochondria are cytoplasmic organelles that regulate both metabolic and apoptotic
signaling pathways; their most highlighted functions include cellular energy generation in …

Alzheimer's disease (AD), the most prevalent dementia in the elderly, is characterized by
progressive synaptic and neuronal loss. Mitochondrial dysfunctions have been consistently …

Alzheimer's disease (AD) is the most common neurodegenerative disorder and is
characterized by progressive memory loss and cognitive decline. One of the hallmarks of AD …

Accumulating evidence points to roles for oxidative stress, amyloid beta (Aβ), and
mitochondrial dysfunction in the pathogenesis of Alzheimer's disease (AD). In neurons, the …

Amyloid-beta peptide (Abeta) is believed to be a central player in the Alzheimer disease
(AD) pathogenesis. However, its mechanisms of toxicity to the central nervous system are …

The amyloid-β peptide (Aβ) has been associated with Alzheimer's disease (AD) for decades.
The original amyloid cascade hypothesis declared that the insoluble extracellular plaques …

Abstract Soluble, secreted Amyloid Precursor Protein-α (sAPPα), a product of α-secretase
(ADAM10) cleavage of Full Length-APP (FL-APP), is a trophic factor critical for synaptic …

In type 2 diabetes (T2D), progressive dysfunction and loss of beta-cells in pancreatic islets
eventually leads to hyperglycemia. The formation of toxic protein aggregates known as islet …

1 Zusammenfassung Die Wirkung von ionisierender Strahlung auf die nukleare DNA
(nDNA) und die daraus resultierenden Schäden und ihre Reparatur sind, verglichen zu der …