Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …

Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …

The association of hepatic mitochondrial function with insulin resistance and non-alcoholic
fatty liver (NAFL) or steatohepatitis (NASH) remains unclear. This study applied high …

Members of the PGC‐1 family of coactivators have been revealed as key players in the
regulation of energy metabolism. Early gain‐and loss‐of‐function studies led to the …

The prevalence of type 2 diabetes (T2D) is rapidly increasing. This is strongly related to the
contemporary lifestyle changes that have resulted in increased rates of overweight …

Aging is associated with alterations in glucose metabolism and sarcopenia that jointly
contribute to a higher risk of developing type 2 diabetes. Because aging is considered as a …

Considering the current trends in life expectancy, women in the modern era are challenged
with facing menopausal symptoms as well as heightened disease risk associated with …

Objectives The aim of this study was to characterize diabetes risk in relation to amount and
distribution of body fat (environmental factors) and genetic risk defined as having first …

Background Mitochondrial alterations have been observed in subjects with metabolic
disorders such as obesity and diabetes. Studies on animal models and cell cultures suggest …

Previous studies have implicated age-associated reductions in mitochondrial oxidative
phosphorylation activity in skeletal muscle as a predisposing factor for intramyocellular lipid …