Chronic kidney disease (CKD) is a worldwide public health threat that increases risk of
death due to cardiovascular complications, including left ventricular hypertrophy (LVH) …

Aims Pathological cardiac hypertrophy is a major predictor for the development of cardiac
diseases. It is associated with chronic neurohumoral stimulation and with altered cardiac …

Objective Physical activity and circadian rhythms are well-established determinants of
human health and disease, but the relationship between muscle activity and the circadian …

Alterations in cerebral cortex connectivity lead to intellectual disability and in Down
syndrome, this is associated with a deficit in cortical neurons that arises during prenatal …

Cardiac muscle adapts to hemodynamic stress by altering myocyte size and function,
resulting in cardiac hypertrophy. Alteration in myocyte calcium homeostasis is known to be …

Aging is the largest risk factor for Alzheimer's disease (AD). Patients with Down syndrome
(DS) develop symptoms consistent with early-onset AD, suggesting that overexpression of …

Background—Cardiac hypertrophy is an early hallmark during the clinical course of heart
failure and is regulated by various signaling pathways. However, the molecular mechanisms …

The purpose of this study was to compare the gene expression profile of mouse skeletal
muscle undergoing two forms of growth (hypertrophy and regrowth) with the goal of …

Anabolic androgens have been shown to reduce muscle loss due to immobilization,
paralysis and many other medical conditions, but the molecular basis for these actions is …

The sarcoplasmic/endoplasmic reticulum Ca2+ ATPases (SERCAs) are the main Ca2+
pumps which decrease the intracellular Ca2+ level by reaccumulating Ca2+ into the …