Emerging drugs for the treatment of knee osteoarthritis
Introduction: Osteoarthritis (OA) is the most prevailing form of joint disease, with symptoms
affecting 10–12% of the adult population with a projection of a 50% increase in prevalence …
affecting 10–12% of the adult population with a projection of a 50% increase in prevalence …
Celecoxib Combined with Diacerein Effectively Alleviates Osteoarthritis in Rats via Regulating JNK and p38MAPK Signaling Pathways
Z Li, D Meng, G Li, J Xu, K Tian, Y Li - Inflammation, 2015 - Springer
Osteoarthritis (OA) has long been a difficult to overcome joint disease for medical workers.
However, there is still a lack of effective treatments for OA. In the present study, we aimed to …
However, there is still a lack of effective treatments for OA. In the present study, we aimed to …
Xanthan gum protects rabbit articular chondrocytes against sodium nitroprusside-induced apoptosis in vitro
Q Chen, X Mei, G Han, P Ling, B Guo, Y Guo… - Carbohydrate …, 2015 - Elsevier
We have previously reported that intra-articular injection of xanthan gum (XG) could
significantly ameliorate the degree of joint cartilage degradation and pain in experimental …
significantly ameliorate the degree of joint cartilage degradation and pain in experimental …
MAPK1 of Leishmania donovani modulates antimony susceptibility by downregulating P-glycoprotein efflux pumps
Emergence of resistance to pentavalent antimonials has become a severe obstacle in the
treatment of visceral leishmaniasis (VL) in the Indian subcontinent. Mitogen-activated protein …
treatment of visceral leishmaniasis (VL) in the Indian subcontinent. Mitogen-activated protein …
Pyrroloquinoline quinone slows down the progression of osteoarthritis by inhibiting nitric oxide production and metalloproteinase synthesis
R Tao, S Wang, X Xia, Y Wang, Y Cao, Y Huang, X Xu… - Inflammation, 2015 - Springer
Osteoarthritis (OA) is the most common arthritis and also one of the major causes of joint
pain in elderly people. The aim of this study was to investigate the effects of pyrroloquinoline …
pain in elderly people. The aim of this study was to investigate the effects of pyrroloquinoline …
[HTML][HTML] Salinomycin causes dedifferentiation via the extracellular signal-regulated kinase (ERK) pathway in rabbit articular chondrocytes
SM Yu, SJ Kim - Journal of Pharmacological Sciences, 2015 - Elsevier
Salinomycin (SAL), a monocarboxylic polyether antibiotic isolated from Streptomyces albus,
modulates various cellular responses, including proliferation, apoptosis, and inflammation …
modulates various cellular responses, including proliferation, apoptosis, and inflammation …
PEP-1-SIRT2 causes dedifferentiation and COX-2 expression via the MAPK pathways in rabbit articular chondrocytes
SIRT2 is a member of the mammalian sirtuin protein family, primarily found in the cytoplasm.
It regulates numerous cellular processes including aging, DNA repair, cell cycle, and …
It regulates numerous cellular processes including aging, DNA repair, cell cycle, and …
Method of effecting de-differentiation of a cell
The invention provides a method of effecting de-differentia tion of an at least partially
differentiated cellor of maintaining pluripotency and/or self-renewing characteristics of an …
differentiated cellor of maintaining pluripotency and/or self-renewing characteristics of an …
[PDF][PDF] Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity
WWC Liou, L Chen, LH Wang, HL Hsu - academia.edu
Overexpression of Shc adaptor proteins is associated with mitogenesis, carcinogenesis and
metastasis. Multiple copies in T-cell malignancy 1 (MCT-1) oncoprotein promotes cell …
metastasis. Multiple copies in T-cell malignancy 1 (MCT-1) oncoprotein promotes cell …
[PDF][PDF] APOPTOTIC-RELATED SIGNALLING PATHWAYS IN MCF-7 CELLS TREATED WITH ETHYL ACETATE EXTRACT OF Dillenia suffruticosa, AND ISOLATION …
T SIM - 2015 - psasir.upm.edu.my
The burden of cancer is expanding at an alarming rate. As in 2012, approximately 14.1
million cancer cases and 8.8 million cancer deaths were reported worldwide. It is expected …
million cancer cases and 8.8 million cancer deaths were reported worldwide. It is expected …