Therapeutic opportunities within the DNA damage response
The DNA damage response (DDR) is essential for maintaining the genomic integrity of the
cell, and its disruption is one of the hallmarks of cancer. Classically, defects in the DDR have …
cell, and its disruption is one of the hallmarks of cancer. Classically, defects in the DDR have …
[HTML][HTML] Mammalian models of chemically induced primary malignancies exploitable for imaging-based preclinical theragnostic research
Y Liu, T Yin, Y Feng, MM Cona, G Huang… - … imaging in medicine …, 2015 - ncbi.nlm.nih.gov
Compared with transplanted tumor models or genetically engineered cancer models,
chemically induced primary malignancies in experimental animals can mimic the clinical …
chemically induced primary malignancies in experimental animals can mimic the clinical …
Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer
Immune checkpoint inhibitors, which unleash a patient's own T cells to kill tumors, are
revolutionizing cancer treatment. To unravel the genomic determinants of response to this …
revolutionizing cancer treatment. To unravel the genomic determinants of response to this …
MicroRNA control of protein expression noise
JM Schmiedel, SL Klemm, Y Zheng, A Sahay… - Science, 2015 - science.org
MicroRNAs (miRNAs) repress the expression of many genes in metazoans by accelerating
messenger RNA degradation and inhibiting translation, thereby reducing the level of protein …
messenger RNA degradation and inhibiting translation, thereby reducing the level of protein …
A simple model-based approach to inferring and visualizing cancer mutation signatures
Y Shiraishi, G Tremmel, S Miyano, M Stephens - PLoS genetics, 2015 - journals.plos.org
Recent advances in sequencing technologies have enabled the production of massive
amounts of data on somatic mutations from cancer genomes. These data have led to the …
amounts of data on somatic mutations from cancer genomes. These data have led to the …
TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases
Background TP53 mutation is more prevalent in therapy-related myeloid neoplasms (t-MN)
than their de novo counterparts; however, the pattern of mutations involving TP53 gene in t …
than their de novo counterparts; however, the pattern of mutations involving TP53 gene in t …
Benzo (a) pyrene induced lung cancer: Role of dietary phytochemicals in chemoprevention
Lung cancer is the major cause of overall cancer deaths, and chemoprevention is a
promising strategy to control this disease. Benzo (a) pyrene [B (a) P], a polycyclic aromatic …
promising strategy to control this disease. Benzo (a) pyrene [B (a) P], a polycyclic aromatic …
[HTML][HTML] Bacterial degradation of monocyclic aromatic amines
PK Arora - Frontiers in microbiology, 2015 - frontiersin.org
Aromatic amines are an important group of industrial chemicals, which are widely used for
manufacturing of dyes, pesticides, drugs, pigments, and other industrial products. These …
manufacturing of dyes, pesticides, drugs, pigments, and other industrial products. These …
Notch1 mutations are drivers of oral tumorigenesis
E Izumchenko, K Sun, S Jones, M Brait… - Cancer prevention …, 2015 - AACR
Disruption of NOTCH1 signaling was recently discovered in head and neck cancer. This
study aims to evaluate NOTCH1 alterations in the progression of oral squamous cell …
study aims to evaluate NOTCH1 alterations in the progression of oral squamous cell …
Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression
As part of the Halifax Project, this review brings attention to the potential effects of
environmental chemicals on important molecular and cellular regulators of the cancer …
environmental chemicals on important molecular and cellular regulators of the cancer …