Pain and poppies: the good, the bad, and the ugly of opioid analgesics

T Trang, R Al-Hasani, D Salvemini… - Journal of …, 2015 - Soc Neuroscience
Treating pain is one of the most difficult challenges in medicine and a key facet of disease
management. The isolation of morphine by Friedrich Sertürner in 1804 added an essential …

The dorsal root ganglion in chronic pain and as a target for neuromodulation: a review

ES Krames - Neuromodulation: Technology at the Neural Interface, 2015 - Elsevier
Background In the not-too-distant past, the dorsal root ganglion (DRG) was portrayed as a
passive neural structure without involvement in the development or maintenance of chronic …

Complex regional pain syndrome type I: a comprehensive review

M Bussa, D Guttilla, M Lucia… - Acta …, 2015 - Wiley Online Library
Background Complex regional pain syndrome type I (CRPS I), formerly known as reflex
sympathetic dystrophy (RSD), is a chronic painful disorder that usually develops after a …

Neuroimmune mechanisms of stress: sex differences, developmental plasticity, and implications for pharmacotherapy of stress-related disease

T Deak, M Quinn, JA Cidlowski, NC Victoria, AZ Murphy… - Stress, 2015 - Taylor & Francis
The last decade has witnessed profound growth in studies examining the role of
fundamental neuroimmune processes as key mechanisms that might form a natural bridge …

Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture

WW Li, TZ Guo, X Shi, Y Sun, T Wei, DJ Clark… - Neuroscience, 2015 - Elsevier
Tibia fracture in rodents induces substance P (SP)-dependent keratinocyte activation and
inflammatory changes in the hindlimb, similar to those seen in complex regional pain …

Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms

RB Griggs, RR Donahue, J Morgenweck, PM Grace… - Pain, 2015 - journals.lww.com
Repeated administration of peroxisome proliferator–activated receptor gamma (PPARg)
agonists reduces neuropathic pain-like behavior and associated changes in glial activation …

Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice

AU Quadros, LG Pinto, MM Fonseca, R Kusuda… - Scientific reports, 2015 - nature.com
The assessment of articular nociception in experimental animals is a challenge because
available methods are limited and subject to investigator influence. In an attempt to solve …

Intrathecal injection of JWH-015 attenuates bone cancer pain via time-dependent modification of pro-inflammatory cytokines expression and astrocytes activity in …

C Lu, Y Liu, B Sun, Y Sun, B Hou, Y Zhang, Z Ma, X Gu - Inflammation, 2015 - Springer
Abstract Cannabinoid receptor type 2 (CB 2) agonists display potential analgesic effects in
acute and neuropathic pain. However, its complex cellular and molecular mechanisms in …

Curcumin attenuates CFA induced thermal hyperalgesia by modulation of antioxidant enzymes and down regulation of TNF-α, IL-1β and IL-6

AK Singh, M Vinayak - Neurochemical research, 2015 - Springer
Reactive oxygen species are signaling mediators of nociceptive pathways. Exogenous
administrations of antioxidants show anti-hyperalgesic effect. However, very little is known …

Microglial interleukin-1β in the ipsilateral dorsal horn inhibits the development of mirror-image contralateral mechanical allodynia through astrocyte activation in a rat …

HS Choi, DH Roh, SY Yoon, JY Moon, SR Choi… - Pain, 2015 - journals.lww.com
Damage on one side of the body can also result in pain on the contralateral unaffected side,
called mirror-image pain (MIP). Currently, the mechanisms responsible for the development …