This chapter is based on the Geoffrey Harris Memorial Lecture presented at the 8th
International Congress of Neuroendocrinology, which was held in Sydney, August 2014. It …

Congenital imprinting disorders (IDs) are characterised by molecular changes affecting
imprinted chromosomal regions and genes, ie genes that are expressed in a parent-of-origin …

Here we describe the insights gained from sequencing the whole genomes of 2,636
Icelanders to a median depth of 20×. We found 20 million SNPs and 1.5 million insertions …

Puberty presents remarkable individual differences in timing reaching over 5 years in
humans. We put emphasis on the two edges of the age distribution of pubertal signs in …

Central precocious puberty (CPP) is characterized by the same biochemical and physical
features as normally timed puberty but occurs at an abnormally early age. Most cases of …

Substantial progress has been made in recent years toward deciphering the molecular and
genetic underpinnings of the pubertal process. The availability of powerful new methods to …

Understanding of the genetic regulation of puberty timing has come largely from studies of
rare disorders and population-based studies in women. Here, we report the largest genomic …

Follicle-stimulating hormone (FSH) plays fundamental roles in male and female fertility. FSH
is a heterodimeric glycoprotein expressed by gonadotrophs in the anterior pituitary. The …

Objectives. We investigated 50-year US trends in age at menarche by socioeconomic
position (SEP) and race/ethnicity because data are scant and contradictory. Methods. We …

Context: Puberty is initiated by a complex interaction of suppressing and stimulating factors.
Genetic studies of familial central precocious puberty have suggested makorin ring finger …