Deubiquitinases and the new therapeutic opportunities offered to cancer
R Pfoh, IK Lacdao, V Saridakis - Endocrine-related cancer, 2015 - erc.bioscientifica.com
Deubiquitinases (DUBs) play important roles and therefore are potential drug targets in
various diseases including cancer and neurodegeneration. In this review, we recapitulate …
various diseases including cancer and neurodegeneration. In this review, we recapitulate …
Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope
D Zattas, M Hochstrasser - Critical Reviews in Biochemistry and …, 2015 - Taylor & Francis
The endoplasmic reticulum (ER) is the primary organelle in eukaryotic cells where
membrane and secreted proteins are inserted into or across cell membranes. Its membrane …
membrane and secreted proteins are inserted into or across cell membranes. Its membrane …
Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine
The current treatment for patients with hypothyroidism is levothyroxine (L-T4) along with
normalization of serum thyroid-stimulating hormone (TSH). However, normalization of serum …
normalization of serum thyroid-stimulating hormone (TSH). However, normalization of serum …
Dysregulation of plasmalogen homeostasis impairs cholesterol biosynthesis
M Honsho, Y Abe, Y Fujiki - Journal of Biological Chemistry, 2015 - ASBMB
Plasmalogen biosynthesis is regulated by modulating fatty acyl-CoA reductase 1 stability in
a manner dependent on cellular plasmalogen level. However, physiological significance of …
a manner dependent on cellular plasmalogen level. However, physiological significance of …