Paediatric patients, particularly preterm neonates, present many pharmacological
challenges. Due to the difficulty in conducting clinical trials in these populations dosing …

In neonates, vancomycin, a narrow-spectrum antibiotic, is the first choice of treatment of late-
onset sepsis predominantly caused by Gram-positive bacteria (coagulase-negative …

Abstract Background and Objective Valproic acid (VPA) follows a non-linear
pharmacokinetic profile in terms of protein-binding saturation. The total daily dose regarding …

Objective Neonatal abstinence syndrome (NAS)—a clinical entity of infants from in utero
exposure to psychoactive xenobiotic and buprenorphine—has been successfully used to …

Mathematical models of drug action and disease progression can inform pediatric
pharmacotherapy. In this tutorial, we explore the key issues that differentiate pediatric from …

Aim: To develop a vancomycin population pharmacokinetic model and assess the
probability of attaining a pharmacodynamic target associated with clinical and …

Background Etomidate is a rapid‐onset, short‐acting hypnotic medication administered for
the induction of anesthesia. It is currently approved by the Food and Drug Administration for …

目的: 通过监测万古霉素血药浓度, 分析万古霉素在感染性疾病新生儿体内消除半衰期的影响
因素, 为临床用药提供参考. 方法: 对2012 年8 月至2014 年7 月收治于湖南省郴州市第一人民 …

Pese a que la vancomicina está disponible hace más de 50 ãnos en el mercado, todavía
quedan aspectos por aclarar sobre el tratamiento de la sepsis neonatal con este antibiótico …

Sources of variability in drug exposure play an important role in evidence-based drug
dosing strategies. Body size representing growth and age representing developmental …