Hsp90: a new player in DNA repair?
R Pennisi, P Ascenzi, A Di Masi - Biomolecules, 2015 - mdpi.com
Heat shock protein 90 (Hsp90) is an evolutionary conserved molecular chaperone that,
together with Hsp70 and co-chaperones makes up the Hsp90 chaperone machinery …
together with Hsp70 and co-chaperones makes up the Hsp90 chaperone machinery …
The unforeseen challenge: from genotype-to-phenotype in cell populations
E Braun - Reports on Progress in Physics, 2015 - iopscience.iop.org
Biological cells present a paradox, in that they show simultaneous stability and flexibility,
allowing them to adapt to new environments and to evolve over time. The emergence of …
allowing them to adapt to new environments and to evolve over time. The emergence of …
The origins of mutational robustness
MA Fares - Trends in Genetics, 2015 - cell.com
Biological systems are resistant to genetic changes; a property known as mutational
robustness, the origin of which remains an open question. In recent years, researchers have …
robustness, the origin of which remains an open question. In recent years, researchers have …
Essential gene disruptions reveal complex relationships between phenotypic robustness, pleiotropy, and fitness
The concept of robustness in biology has gained much attention recently, but a mechanistic
understanding of how genetic networks regulate phenotypic variation has remained elusive …
understanding of how genetic networks regulate phenotypic variation has remained elusive …
Transcriptional derepression uncovers cryptic higher-order genetic interactions
MB Taylor, IM Ehrenreich - PLoS genetics, 2015 - journals.plos.org
Disruption of certain genes can reveal cryptic genetic variants that do not typically show
phenotypic effects. Because this phenomenon, which is referred to as 'phenotypic …
phenotypic effects. Because this phenomenon, which is referred to as 'phenotypic …
[图书][B] Restorative free will: Back to the biological base
BN Waller - 2015 - books.google.com
Restorative Free Will argues for an account of free will that takes seriously the evolutionary
development of the key elements of free will. It emphasizes a biological understanding of …
development of the key elements of free will. It emphasizes a biological understanding of …
Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to …
MA Varela - BMC genomics, 2015 - Springer
Background Genome-wide association studies show that most human traits and diseases
are caused by a combination of environmental and genetic causes, with each one of these …
are caused by a combination of environmental and genetic causes, with each one of these …
[HTML][HTML] Adenomatous polyposis coli mutants dominantly activate Hsf1-dependent cell stress pathways through inhibition of microtubule dynamics
Cancer cells up-regulate cell stress pathways, including the protein chaperone Hsp90.
Increases in Hsp90 are believed “buffer” mutant protein activities necessary for cancer …
Increases in Hsp90 are believed “buffer” mutant protein activities necessary for cancer …
Gene therapy against HSP90: glucocorticoid receptor-assisted cancer treatment
SS Adhikari, SK Mondal, R Banerjee - Heat shock protein-based therapies, 2015 - Springer
Abstract Heat shock protein 90 (HSP90) is an ideal target for cancer because of its involved
participation in multiple cancer-implicated pathways that characterize various hallmarks of …
participation in multiple cancer-implicated pathways that characterize various hallmarks of …
Modulación de la localización subcelular de factores nucleares por proteínas TPR
GI Mazaira - 2015 - bibliotecadigital.exactas.uba.ar
Los dominios TPR están constituidos secuencias en tándem de 34
aminoácidosorganizadas en α-hélices antiparalelas. Las proteínas TPR mejor …
aminoácidosorganizadas en α-hélices antiparalelas. Las proteínas TPR mejor …