Nucleic acid therapeutics using polyplexes: a journey of 50 years (and beyond)

U Lächelt, E Wagner - Chemical reviews, 2015 - ACS Publications
Since the elucidation of the molecular structure of nucleic acids and understanding of their
role in encoding and translating genetic information into biological function, 1 the knowledge …

Polymeric nanostructures for imaging and therapy

M Elsabahy, GS Heo, SM Lim, G Sun… - Chemical …, 2015 - ACS Publications
Medical diagnosis and therapy are essential for providing patients with proper care,
although inefficient diagnosis and therapy are usually associated with either improper …

A holistic approach to targeting disease with polymeric nanoparticles

CJ Cheng, GT Tietjen, JK Saucier-Sawyer… - Nature reviews Drug …, 2015 - nature.com
The primary goal of nanomedicine is to improve clinical outcomes. To this end, targeted
nanoparticles are engineered to reduce non-productive distribution while improving …

Self-assembly of DNA nanohydrogels with controllable size and stimuli-responsive property for targeted gene regulation therapy

J Li, C Zheng, S Cansiz, C Wu, J Xu, C Cui… - Journal of the …, 2015 - ACS Publications
Here, we report the synthesis and characterization of size-controllable and stimuli-
responsive DNA nanohydrogels as effective targeted gene delivery vectors. DNA …

[HTML][HTML] Understanding and exploiting nanoparticles' intimacy with the blood vessel and blood

MI Setyawati, CY Tay, D Docter, RH Stauber… - Chemical Society …, 2015 - pubs.rsc.org
While the blood vessel is seldom the target tissue, almost all nanomedicine will interact with
blood vessels and blood at some point of time along its life cycle in the human body …

[HTML][HTML] Going beyond the liver: progress and challenges of targeted delivery of siRNA therapeutics

C Lorenzer, M Dirin, AM Winkler, V Baumann… - Journal of Controlled …, 2015 - Elsevier
Therapeutic gene silencing promises significant progress in pharmacotherapy, including
considerable expansion of the druggable target space and the possibility for treating orphan …

Accelerating the translation of nanomaterials in biomedicine

S Mitragotri, DG Anderson, X Chen, EK Chow, D Ho… - ACS …, 2015 - ACS Publications
Due to their size and tailorable physicochemical properties, nanomaterials are an emerging
class of structures utilized in biomedical applications. There are now many prominent …

Progress in material design for biomedical applications

MW Tibbitt, CB Rodell, JA Burdick… - Proceedings of the …, 2015 - National Acad Sciences
Biomaterials that interface with biological systems are used to deliver drugs safely and
efficiently; to prevent, detect, and treat disease; to assist the body as it heals; and to engineer …

Dual targeted immunotherapy via in vivo delivery of biohybrid RNAi‐peptide nanoparticles to tumor‐associated macrophages and cancer cells

J Conde, C Bao, Y Tan, D Cui… - Advanced functional …, 2015 - Wiley Online Library
Lung cancer is associated with very poor prognosis and considered one of the leading
causes of death worldwide. Here, highly potent and selective biohybrid RNA interference …

Modified polynucleotides for the production of secreted proteins

T Chakraborty, A De Fougerolles - US Patent 9,192,651, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49235350&utm_source= google_patent&utm_medium= platform_link&utm_campaign …