OA is a degenerative joint disease characterized by articular cartilage degradation,
osteophyte formation, synovitis, and subchondral bone sclerosis. One of OAs main risk …

Osteoarthritis (OA), the most common form of arthritis, is a disabling degenerative joint
disease affecting synovial joints and is associated with cartilage destruction, inflammation of …

Objective Synovitis associated with osteoarthritis (OA) is directly responsible for several
clinical symptoms and reflects OA's structural progression. This study sought to analyze the …

Background Multinucleated giant cells have been noticed in diverse arthritic conditions
since their first description in rheumatoid synovium. However, their role in the pathogenesis …

Objectives Blockade of transient receptor potential vanilloid 1 (TRPV1) with systemic
antagonists attenuates osteoarthritis (OA) pain behaviour in rat models, but on-target …

It is still controversial which cell types are responsible for synovial inflammation in
osteoarthritic (OA) joints. The aim of this study was to quantify the mononuclear cell …

The synovium is an intra-articular mesenchymal tissue and essential for the normal joint
function. It is involved in many pathological characteristic processes and sometimes specific …

Objectives Synovial fluid glutamate concentrations increase in arthritis. Activation of kainate
(KA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate …

Objective Intra-articular steroid injection has been widely used in the management of
symptomatic osteoarthritis; however, its frequent use is avoided since there is an increase in …

Considering the high prevalence of osteoarthritis (OA) and since until now there has not
been any human studies to evaluate the effect of sesame in OA patients, this study was …