The introduction of vaccination in the 1950s significantly reduced the morbidity and mortality
of pertussis. However, since the 1990s, a resurgence of pertussis has been observed in …

Pertussis toxin (PT) is a multisubunit protein toxin secreted by Bordetella pertussis, the
bacterial agent of the disease pertussis or whooping cough. PT in detoxified form is a …

An analysis assessing for associations between pertactin production and both clinical
presentation and vaccine history found a significant association between vaccination and …

Whooping cough or pertussis is a highly infectious respiratory disease in humans caused by
Bordetella pertussis. The use of acellular vaccines (ACV) has been associated with the …

Despite more than 50 years of vaccination, pertussis is still an endemic disease, with regular
epidemic outbreaks. With the exception of Poland, European countries have replaced whole …

Background: Australia recently experienced its worst pertussis epidemic since introduction
of pertussis vaccine into the National Immunisation Program. This study aimed to determine …

Objectives To investigate changes in virulence-related genotypes and in the antimicrobial
susceptibility of Bordetella pertussis isolates collected from the 1970s to 2014 in the …

Pertussis continues to be an important public-health issue. The high immunization coverage
rates achieved, mainly in industrialized countries, have certainly decreased the spread of …

Evolution of Bordetella pertussis is driven by natural and vaccine pressures. Isolates
circulating in regions with high vaccination coverage present multiple allelic and antigenic …

Herd immunity can potentially induce a change of circulating viruses. However, it remains
largely unknown that how bacterial pathogens adapt to vaccination. In this study, Bordetella …