Most organisms experience changes in regenerative abilities through their lifespan. During
aging, numerous tissues exhibit a progressive decline in homeostasis and regeneration that …

Cellular senescence is a state of permanent growth arrest and is thought to play a pivotal
role in tumor suppression. Cellular senescence may play an important role in tumor …

Background—Sirt7, 1 of the 7 members of the mammalian sirtuin family, promotes
oncogenic transformation. Tumor growth and metastasis require fibrotic and angiogenic …

Radiotherapy is a major cancer treatment option but dose-limiting side effects such as late-
onset fibrosis in the irradiated tissue severely impair quality of life in cancer survivors. Efforts …

Since its first description over 50 years ago, cellular senescence has gained increasing
attention. The number of research publications on cellular senescence last year alone is …

Objective To observe the effect of transforming growth factor beta 1 (TGF-β1) on the
expression of collagen in rat atrial and ventricular fibroblasts, and to investigate its specific …

Le vieillissement est considéré comme un facteur de risque majeur pour les maladies
chroniques. Parmi elles, l'insuffisance cardiaque occupe une place de premier plan et …

Aging is characterized by a decline in an organism's ability to adapt and respond to its
surroundings and poses one of the greatest risk factors for many human diseases. One of …

THE ROLE OF THE STRESS RESPONSE GENE GADD45B IN SENESCENCE A Dissertation
Submitted to the Temple University Graduate Board In P Page 1 i THE ROLE OF THE STRESS …

Cardiac fibrosis is the final common pathway of most chronic heart diseases, resulting in
progressive loss of cardiac function and heart failure. Despite of morbidity and mortality …