PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled …

FJ Raal, EA Stein, R Dufour, T Turner, F Civeira… - The Lancet, 2015 - thelancet.com
Background Heterozygous familial hypercholesterolaemia is characterised by low cellular
uptake of LDL cholesterol, increased plasma LDL cholesterol concentrations, and premature …

Prevalence and management of familial hypercholesterolaemia in coronary patients: an analysis of EUROASPIRE IV, a study of the European Society of Cardiology

G De Backer, J Besseling, J Chapman, GK Hovingh… - Atherosclerosis, 2015 - Elsevier
Background Familial hypercholesterolaemia (FH) is a hereditary disorder predisposing to
premature coronary heart disease (CHD) and is until now mainly diagnosed clinically on the …

Familial hypercholesterolemia in Brazil: cascade screening program, clinical and genetic aspects

CE Jannes, RD Santos, PR de Souza Silva, L Turolla… - Atherosclerosis, 2015 - Elsevier
Background: There is little knowledge about familial hypercholesterolemia in Brazil. This
study presents the first results of genetic cascade screening performed in the city of Sao …

Antioxidant, hypolipidemic, and anti-angiotensin-1-converting enzyme properties of lemon (Citrus limon) and lime (Citrus aurantifolia) juices

G Oboh, FO Bello, AO Ademosun, AJ Akinyemi… - Comparative Clinical …, 2015 - Springer
Lemon (Citrus limon) and lime (Citrus aurantifolia) juices are used in folk medicine for the
management of hypertension and other cardiovascular diseases, but the mechanism of …

[HTML][HTML] Statins: Cholesterol guidelines and Indian perspective

AS Menon, N Kotwal, Y Singh… - Indian Journal of …, 2015 - journals.lww.com
Statins have become an important drug in preventing the occurrence of atherosclerotic
cardiovascular disease (ASCVD). The effectiveness of statins in reducing ASCVD has been …

[HTML][HTML] Заключение совета экспертов Национального общества по изучению атеросклероза (НОА). Семейная гиперхолестеринемия в Российской …

ЮА Карпов, ВВ Кухарчук, СА Бойцов - Атеросклероз и …, 2015 - cyberleninka.ru
Нарушения липидного обмена вносят существенный вклад в развитие осложнений
атеросклероза. Семейная гиперхолестеринемия (СГХС) является наиболее частой …

Challenges in the care of familial hypercholesterolemia: a community care perspective

T Brett, GF Watts, DE Arnold-Reed, DA Bell… - Expert Review of …, 2015 - Taylor & Francis
Familial hyperchoelsterolaemia (FH) remains under-diagnosed and under-treated in the
community setting. Earlier evidence suggested a prevalence of 1: 500 worldwide but newer …

LDL-R promoting activity of peptides derived from human PCSK9 catalytic domain (153–421): design, synthesis and biochemical evaluation

RH Alghamdi, P O'Reilly, C Lu, J Gomes… - European journal of …, 2015 - Elsevier
Abstract Background High level of Low Density Lipoprotein-Cholesterol (LDL-C) in
circulation in the blood is associated with an elevated risk of cardiovascular disease (CVD) …

Cost-effectiveness analysis of alternative screening and treatment strategies for heterozygous familial hypercholesterolemia in the United States

CX Chen, JW Hay - International journal of cardiology, 2015 - Elsevier
Background/objectives Familial hypercholesterolemia (FH) is a genetic disorder that leads to
premature heart disease or stroke if untreated. Statins are effective for individuals with FH …

Cascade screening of familial hypercholesterolemia must go on

JMH Galema-Boers, J Versmissen, HWOR van Lennep… - Atherosclerosis, 2015 - Elsevier
Purpose This study assesses the success of the recently terminated Dutch nationwide
cascade screening by examining whether children with familial hypercholesterolemia (FH) …