Over 80% of ovarian cancer patients develop chemoresistance which results in a lethal
course of the disease. A well-established cause of chemoresistance involves the family of …

Methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl) are coenzymes for methionine
synthase and methylmalonyl‐CoA mutase, respectively. Hydroxylcobalamin (HOCbl) and …

Данные клинические рекомендации подготовлены совместно с Всероссийской
ассоциацией для больных муковисцидозом, рассмотрены и утверждены на заседании …

Vitamin B12, also known as cobalamin, is a water-soluble vitamin that is important in the
hematological and nervous systems, and it has a complex relationship with the skin. Altered …

Newborn screening (NBS) is justified if early intervention is effective in a disorder generally
not detected early in life on a clinical basis, and if sensitive and specific biochemical markers …

Peroxisomes are arguably the most biochemically versatile of all eukaryotic organelles.
Their metabolic functions vary between different organisms, between different tissue types of …

Methylenetetrahydrofolate reductase (MTHFR) deficiency is the most common inherited
disorder of folate metabolism and causes severe hyperhomocysteinaemia. To better …

Retinal development requires precise temporal and spatial coordination of cell cycle exit,
cell fate specification, cell migration and differentiation. When this process is disrupted …

Human CblC catalyzes the elimination of the upper axial ligand in cobalamin or B 12
derivatives entering the cell from circulation. This processing step is critical for assimilation …

The physiology of human skin pigmentation is varied and complex, with an extensive
melanogenic paracrine network involving mesenchymal and epithelial cells, contributing to …