In recent years, a number of novel tandem mass spectrometry approaches utilizing radical‐
driven peptide gas‐phase fragmentation chemistry have been developed. These …

Synthetic application of aminoketyl radicals [R–C•(O–) NR′ R ″] formed by a direct
electron capture into the amide bond is limited. Herein, we demonstrate addition of …

The application of ion pre-activation with 266 nm ultraviolet (UV) laser irradiation combined
with electron capture dissociation (ECD) is demonstrated to enhance top-down mass …

We investigate the mechanism of disulfide bond cleavage in gaseous peptide and protein
ions initiated by a covalently-attached regiospecific acetyl radical using mass spectrometry …

Characterization of acidic peptides and proteins is greatly hindered due to lack of suitable
analytical techniques. Here we present the implementation of 213 nm ultraviolet …

Several approaches for the generation of peptide radical cations using ion/ion reactions
coupled with either collision induced dissociation (CID) or ultraviolet photo dissociation …

This work describes investigation of the fragmentation mechanism of tryptophan N-indolyl
radical cation, H3N+-TrpN•(m/z 204) studied via DFT calculations and several gas-phase …

In femtosecond encounters between peptide cations and alkali metal atoms, electron
transfer occurs from the latter to the former. The peptide radicals are born in the same …

The electron capture dissociation and collision induced dissociation of doubly and triply
charged ions of peptides RPLGMSPFK, RPLGM (Se) SPFK and RPLGM (O) SPFK were …

Conventional tandem mass spectrometry relies on even-electron fragmentation that
provides limited structural information for glycerophospholipids (GP), which are key …